We have produced the first 30 m resolution global land-cover maps using Landsat Thematic Mapper (TM) and Enhanced Thematic Mapper Plus (ETM+) data. We have classified over 6600 scenes of Landsat TM data after 2006, and over 2300 scenes of Landsat TM and ETM+ data before 2006, all selected from the green season. These images cover most of the world's land surface except Antarctica and Greenland. Most of these images came from the United States Geological Survey in level L1T (orthorectified). Four classifiers that were freely available were employed, including the conventional maximum likelihood classifier (MLC), J4.8 decision tree classifier, Random Forest (RF) classifier and support vector machine (SVM) classifier. A total of 91,433 training samples were collected by traversing each scene and finding the most representative and homogeneous samples. A total of 38,664 test samples were collected at preset, fixed locations based on a globally systematic unaligned sampling strategy. Two software tools, Global Analyst and Global Mapper developed by extending the functionality of Google Earth, were used in developing the training and test sample databases by referencing the Moderate Resolution Imaging Spectroradiometer enhanced vegetation index (MODIS EVI) time series for 2010 and high resolution images from Google Earth. A unique land-cover classification system was developed that can be crosswalked to the existing United Nations Food and Agriculture Organization (FAO) land-cover classification system as well as the International Geosphere-Biosphere Programme (IGBP) system. Using the four classification algorithms, we obtained the initial set of global land-cover maps. The SVM produced the highest overall classification accuracy (OCA) of 64.9% assessed with our test samples, with RF (59.8%), J4.8 (57.9%), and MLC (53.9%) ranked from the second to the fourth. We also estimated the OCAs using a subset of our test samples (8629) each of which represented a homogeneous area greater than 500 m × 500 m. Using this subset, we found the OCA for the SVM to be 71.5%. As a consistent source for estimating the coverage of global land-cover types in the world, estimation from the test samples shows that only 6.90% of the world is planted for agricultural production. The total area of cropland is 11.51% if unplanted croplands are included. The forests, grasslands, and shrublands cover 28.35%, 13.37%, and 11.49% of the world, respectively. The impervious surface covers only 0.66% of the world. Inland waterbodies, barren lands, and snow and ice cover 3.56%, 16.51%, and 12.81% of the world, respectively.

Since the launch of the first land-observation satellite (Landsat-1) in 1972, land-cover mapping has accumulated a wide range of knowledge in the peer-reviewed literature. However, this knowledge has never been comprehensively analysed for new discoveries. Here, we developed the first spatialized database of scientific literature in English about land-cover mapping. Using this database, we tried to identify the spatial temporal patterns and spatial hotspots of land-cover mapping research around the world. Among other findings, we observed (1) a significant mismatch between hotspot areas of land-cover mapping and areas that are either hard to map or rich in biodiversity; (2) mapping frequency is positively related to economic conditions; (3) there is no obvious temporal trend showing improvement in mapping accuracy; (4) images with more spectral bands or a combination of data types resulted in increased mapping accuracies; (5) accuracy differences due to algorithm differences are not as large as those due to various types of data used; and (6) the complexity of a classification system decreases its mapping accuracy. We recommend that one way to improve our understanding of the challenges, advances, and applications of previous land-cover mapping is for journals to require area-based information at the time of manuscript submission. In addition, building a standard protocol for systematic assessment of land-cover mapping efforts at the global scale through international collaboration is badly needed.

As the world’s fastest spreading vector-borne disease, dengue was estimated to infect more than 390 million people in 2010, a 30-fold increase in the past half century. Although considered to be a non-endemic country, mainland China had 55,114 reported dengue cases from 2005 to 2014, of which 47,056 occurred in 2014. Furthermore, 94% of the indigenous cases in this time period were reported in Guangdong Province, 83% of which were in Guangzhou City. In order to determine the possible determinants of the unprecedented outbreak in 2014, a population-based deterministic model was developed to describe dengue transmission dynamics in Guangzhou. Regional sensitivity analysis (RSA) was adopted to calibrate the model and entomological surveillance data was used to validate the mosquito submodel. Different scenarios were created to investigate the roles of the timing of an imported case, climate, vertical transmission from mosquitoes to their offspring, and intervention. The results suggested that an early imported case was the most important factor in determining the 2014 outbreak characteristics. Precipitation and temperature can also change the transmission dynamics. Extraordinary high precipitation in May and August, 2014 appears to have increased vector abundance. Considering the relatively small number of cases in 2013, the effect of vertical transmission was less important. The earlier and more frequent intervention in 2014 also appeared to be effective. If the intervention in 2014 was the same as that in 2013, the outbreak size may have been over an order of magnitude higher than the observed number of new cases in 2014.The early date of the first imported and locally transmitted case was largely responsible for the outbreak in 2014, but it was influenced by intervention, climate and vertical transmission. Early detection and response to imported cases in the spring and early summer is crucial to avoid large outbreaks in the future. Dengue has not been considered to be a major problem in China since it is recognized as an imported disease and only 8,058 cases were reported from 2005 to 2013. However, in 2014 alone, 47,056 new cases were reported. In this study, a mathematical model was developed to determine the possible cause of this outbreak. The most important parameters found to underlie the pattern of a small outbreak in 2013 and a much larger one in 2014 was the timing of the first imported and locally transmitted case. The importance of precipitation and temperature was also confirmed by the simulation results under different climate scenarios. The model also suggests that the earlier and more frequent control interventions in 2014 targeting immature mosquitoes, such as emptying water containers, and adult control, were effective in preventing larger outbreaks. Furthermore, more attention should be paid to imported cases occurring between March 1^st and July 1^st to prevent early and prolonged transmission. Without early detection and response, the final outbreak size might otherwise be an order of magnitude or more the size when the imported case occurred outside this time period.

Significance: Food system collapse incurs major societal costs that may extend across generations. The Great Chinese Famine—widely acknowledged as the largest famine in human history—was associated with tremendous short-term adverse health consequences, yet its long-term effect on infectious disease incidence has not been estimated. We conducted a cohort analysis of >1 million pulmonary tuberculosis (PTB) cases in a major center of ongoing transmission that experienced high famine mortality, finding a substantial burden of active PTB potentially attributable to the famine in the birth cohort that experienced prenatal and early-life exposure to famine, as well in their putative offspring. The Great Chinese Famine occurred >60 y ago, yet continues to contribute to the high PTB burden in China.

Climate exerts complex influences on leptospirosis transmission, affecting human behavior, zoonotic host population dynamics, and survival of the pathogen in the environment. Here, we describe the spatiotemporal distribution of leptospirosis incidence reported to China’s National Infectious Disease Surveillance System from 2004–2014 in an endemic region in western China, and employ distributed lag models at annual and sub-annual scales to analyze its association with hydroclimatic risk factors and explore evidence for the potential role of a soil reservoir in the transmission of Leptospira spp. More than 97% of the 2,934 reported leptospirosis cases occurred during the harvest season between August and October, and most commonly affected farmers (83%). Using a distributed-lag Poisson regression framework, we characterized incidence rate ratios (IRRs) associated with interquartile range increases in precipitation of 3.45 (95% confidence interval 2.57–4.64) over 0-1-year lags, and 1.90 (1.18–3.06) over 0-15-week lags. Adjusting for soil moisture decreased IRRs for precipitation at both timescales (yearly adjusted IRR: 1.05, 0.74–1.49; weekly adjusted IRR: 1.36, 0.72–2.57), suggesting precipitation effects may be mediated through soil moisture. Increased soil moisture was positively associated with leptospirosis at both timescales, suggesting that the survival of pathogenic Leptospira spp. in moist soils may be a critical control on harvest-associated leptospirosis transmission in the study region. These results support the hypothesis that soils may serve as an environmental reservoir and may play a significant yet underrecognized role in leptospirosis transmission. Leptospirosis is among the leading causes of morbidity from zoonotic infections worldwide, affecting populations that are exposed to contaminated water. The disease is caused by Leptospira spp. bacteria, which are transmitted to humans either through direct contact with infected animals, or indirectly through the environment. Climatic conditions can influence transmission by altering human exposure, animal host population dynamics, and environmental conditions that allow Leptospira spp. to persist in the environment (e.g., moist environments, warm temperatures). Here, we investigated the spatiotemporal distribution of leptospirosis cases in a rural setting in western China and estimated the association between hydroclimatic conditions and leptospirosis incidence. We found that incidence of leptospirosis—especially high amongst farmers—may be associated with rice harvest, and modulated by prior bacterial accumulation within the soil under moist conditions. These results corroborate previous findings that soils may be underrecognized environmental reservoirs of pathogenic Leptospira spp., and that their role in explaining leptospirosis incidence should be considered when developing prevention programs.