Multifunctional Re(i) tricarbonyls including phenanthroline derivatives and Clotrimazole showed high activity against Trypanosoma cruzi and inhibited parasite lanosterol 14-α-demethylase (CYP51).
[VIVO(L-H)2] and [VVO(OCH3)(L-H)2] compounds of 8-hydroxyquinoline derivatives L showed activity againstTrypanosoma cruziandLeishmania infantumand high selectivities. Metallomics and interaction with BSA, apo-HTF and DNA were studied.