Levodopa/carbidopa intestinal gel infusion is a treatment option for patients of advanced stage of Parkinson's disease. This treatment requires the time-consuming and error-prone conversion of orally taken antiparkinson drugs into an equivalent replacing dose of levodopa/carbidopa, which is delivered via pump. In order to facilitate and speed up this conversion process, we developed a specific user-friendly application that would be available online or as a standalone mobile application. Such an application has now been written and designed in collaboration with a computer scientist and physician, who is also intended to be the final user. The levodopa equivalent dose calculations are based on previous studies and data reported in the literature. Two related on-line conversion applications were analyzed and evaluated. The primary objectives of the application were determined, and basic functionalities were outlined. The application was implemented using modern development tools and frameworks. The application has proven to be effective and easy to use in our clinical setting. It can serve as a control for manual calculations made by medical staff. It can also be applied as a useful tool in levodopa/carbidopa intestinal gel infusion courses for the advanced treatment of Parkinson's disease. The presented application could replace the tedious and error-prone levodopa equivalent dose conversion of antiparkinson drugs efficiently. In comparison to related on-line conversion applications, this specific application provides more functionality, reduces the risk of user errors, and can be run on a variety of devices. The conversion value provided by the application is only an estimate. The effect of the drugs is specific for each individual patient, which could not be considered in the calculations. Therefore, the responsibility of using the results of the application rests with the clinical judgment of the user. Nevertheless, the application can give us a good starting point for the initial pump setting, which would be adjusted further during the titration period, according to the patient's response.

This paper proposes a hybrid machine translation (HMT) system that improves the quality of neural machine translation (NMT) by incorporating statistical machine translation (SMT). Therefore, two NMT systems and two SMT systems were built for the Slovenian–English language pair, each for translation in one direction. We used a multilingual language model to embed the source sentence and translations into the same vector space. From each vector, we extracted features based on the distances and similarities calculated between the source sentence and the NMT translation, and between the source sentence and the SMT translation. To select the best possible translation, we used several well-known classifiers to predict which translation system generated a better translation of the source sentence. The proposed method of combining SMT and NMT in the hybrid system is novel. Our framework is language-independent and can be applied to other languages supported by the multilingual language model. Our experiment involved empirical applications. We compared the performance of the classifiers, and the results demonstrate that our proposed HMT system achieved notable improvements in the BLEU score, with an increase of 1.5 points and 10.9 points for both translation directions, respectively.

Growing amounts of municipal waste and the need for efficient recycling demand automated and accurate classification systems. This paper investigates deep learning approaches for multi-class waste sorting based on image data, comparing three widely used convolutional neural network architectures (ResNet-50, EfficientNet-B0, and MobileNet V3) with a custom hybrid model (CustomNet). The dataset comprises 13,933 RGB images across 10 waste categories, combining publicly available samples from the Kaggle Garbage Classification dataset (61.1%) with images collected in house (38.9%). The three glass sub-categories (brown, green, and white glass) were merged into a single glass class to ensure consistent class representation across all dataset splits. Preprocessing steps include normalization, resizing, and extensive data augmentation to improve robustness and mitigate class imbalance. Transfer learning is applied to pretrained models, while CustomNet integrates feature representations from multiple backbones using projection layers and attention mechanisms. Performance is evaluated using accuracy, macro-F1, and ROC–AUC on a held-out test set. Statistical significance was assessed using paired t-tests and Wilcoxon signed-rank tests with Bonferroni correction across five-fold cross-validation runs. The results show that CustomNet achieves 97.79% accuracy, a macro-F1 score of 0.973, and a ROC–AUC of 0.992. CustomNet significantly outperforms EfficientNet-B0 and MobileNet V3 ($p<0.001$, Bonferroni corrected), and it achieves performance parity with ResNet-50 ($p=0.383$) at a substantially lower parameter count in the classification head (9.7 M vs. 25.6 M). These findings indicate that combining multiple feature extractors with attention mechanisms improves classification performance, supports qualitative model explainability via saliency visualization (Grad-CAM), and enables practical deployment on heterogeneous Edge AI platforms. Inference benchmarking on an NVIDIA Jetson Orin Nano demonstrated real-world deployment feasibility at 86.70 ms per image (11.5 FPS).

This paper assesses the fault-detection capabilities of modern deep-learning models. It highlights that a naive deep-learning approach optimized for accuracy is unsuitable for learning fault-detection models from time-series data. Consequently, out-of-the-box deep-learning strategies may yield impressive accuracy results but are ill-equipped for real-world applications. The paper introduces a methodology for estimating fault-detection delays when no oracle information on fault occurrence time is available. Moreover, the paper presents a straightforward approach to implicitly achieve the objective of minimizing fault-detection delays. This approach involves using pseudo-multi-objective deep optimization with data windowing, which enables the utilization of standard deep-learning methods for fault detection and expanding their applicability. However, it does introduce an additional hyperparameter that needs careful tuning. The paper employs the Tennessee Eastman Process dataset as a case study to demonstrate its findings. The results effectively highlight the limitations of standard loss functions and emphasize the importance of incorporating fault-detection delays in evaluating and reporting performance. In our study, the pseudo-multi-objective optimization could reach a fault-detection accuracy of 95% in just a fifth of the time it takes the best naive approach to do so.

When it comes to game playing, evolutionary and tree-based approaches are the most popular approximate methods for decision making in the artificial intelligence field of game research. The evolutionary domain therefore draws its inspiration for the design of approximate methods from nature, while the tree-based domain builds an approximate representation of the world in a tree-like structure, and then a search is conducted to find the optimal path inside that tree. In this paper, we propose a novel metric for game feature validation in Real-Time Strategy (RTS) games. Firstly, the identification and grouping of Real-Time Strategy game features is carried out, and, secondly, groups are included into weighted classes with regard to their correlation and importance. A novel metric is based on the groups, weighted classes, and how many times the playtesting agent invalidated the game feature in a given game feature scenario. The metric is used in a series of experiments involving recent state-of-the-art evolutionary and tree-based playtesting agents. The experiments revealed that there was no major difference between evolutionary-based and tree-based playtesting agents.

Implementation of Massive Artificial Neural Networks with CUDA | InTechOpen, Published on: 2012-04-05. Authors: Domen Verber