Our laboratory has a long-standing interest in uncovering the cellular and molecular mechanisms for decoding the developmental and developmental disorders of the central nervous system. The main academic achievements include: 1) Deciphering the novel signaling mechanisms underlying the neural precursor cell fate determination and differentiation during early cortical development. We identified that the adaptor protein Rack1 and O-GlcNAcylation play critical roles in regulating cerebellar development [PNAS 2019, 2022; Cell Reports 2021 (Cover paper); Front Cell Neurosci 2019; CNS Neurosci Ther 2021]. 2) Decoding the neurobiological mechanisms underlying autism and social behavior defects. We identified for the first time that the autism pathogenic gene human MeCP2 protein at Threonine 203 was a key site of O-GlcNAcylation modification, and MeCP2 T203M mutation is highly related to the etiology of Rett syndrome (Neuroscience Bulletin 2022，Cover paper). Based on the innovative “miniature two-photon” microscope calcium imaging technology, we analyzed the neuronal coding mechanisms underlying the social behavior deficits in freely moving MeCP2 transgenic autism mouse model (Sci Adv. 2022). Our studies not only provide novel cellular and molecular insights to advance our understanding of the etiology of autism in-depth, but also provide novel ideas for the precise intervention and treatment of neurodevelopmental disorders.