Synthesis of polymethyl-methacrylate–collagen graft copolymer was carried out upon initiation of the process by radicals formed by irradiation with visible light (λ = 400–700 nm) of the complex oxide RbTe_1.5W_0.5O₆ at a temperature of 25°C. The characteristics of the new polymer material were obtained by the methods of elemental and physicochemical analyzes.

Grafted copolymers of gelatin and polymethyl methacrylate are synthesized using the tributylboron–oxygen initiating system in an aqueous dispersion at 60°C. The products are characterized by IR spectroscopy and gel permeation chromatography. The proportion of polymethyl methacrylate in the copolymer is 2–60% and increases with a higher concentration of alkylborane in the initial mixture. The particle size of the aqueous dispersions of the copolymers determined by dynamic light scattering exceeds the particle size of gelatin. The thermogravimetric curves of the copolymers are similar to those of gelatin, with thermal stability tending to increase with a higher concentration of tributylboron. All the copolymers are biodegradable by fungi.

Enzymatic hydrolysis of native collagen and fibrinogen was carried out under comparable conditions at room temperature. The molecular weight parameters of proteins before and after hydrolysis by thrombin were monitored by gel-penetrating chromatography (GPC). An analysis of the experiment results shows that the molecular weight parameters of the initial fibrinogen (Fn) and cod collagen (CC) are very similar. High molecular CC decays within the first minute, forming two low molecular fractions. The main part (~80%) falls on the fraction with a value of M_w less than 10 kDa. The initial high molecular fraction of Fn with M_w ~320–340 kDa is not completely hydrolyzed even after three days of control. The presence of low molecular fractions with M_w ~17 and M_w ~10 kDa in the solution slightly increases within an hour and noticeably increases for three days. The destruction of macromolecules of high molecular collagen to hydrolysis products appears almost completely within the first minute mainly to the polymer with M_w ~10 kDa, and enzymatic hydrolysis of fibrinogen proceeds slower than that of collagen, but also mainly to the polymer with M_w ~10 kDa. Comparative photos of the surfaces of native collagen, fibrinogen and the scaffold based on them were obtained.

Graft copolymers of collagen and polyacrylamide (PAA) were synthesized in a suspension of acetic acid dispersion of fish collagen and acrylamide (AA) in the presence of tributylborane (TBB). The characteristics of the copolymers were determined using infrared spectroscopy and gel permeation chromatography (GPC). Differences in synthesis temperature between 25 and 60 °C had no significant effect on either proportion of graft polyacrylamide generated or its molecular weight. However, photomicrographs taken with the aid of a scanning electron microscope showed a breakdown of the fibrillar structure of the collagen within the copolymer at synthesis temperatures greater than 25 °C. The mechanical properties of the films and the cytotoxicity of the obtained copolymer samples were studied. The sample of a hybrid copolymer of collagen and PAA obtained at 60 °C has stronger mechanical properties compared to other tested samples. Its low cytotoxicity, when the monomer is removed, makes materials based on it promising in scaffold technologies.