The laccase-catalyzed oxidation of 1,4-dihydropyridines to pyridines using aerial O₂ as the oxidant exclusively delivers pyridines with yields up to 95% under mild reaction conditions. Combination of the Hantzsch 1,4-dihydropyridine synthesis with the newly developed laccase-catalyzed oxidation forms the basis of a facile and environmentally benign method for the synthesis of pyridines in one pot.

The laccase-catalyzed oxidative phenolic coupling of vanillidene derivatives using aerial oxygen as the oxidant has been developed. Depending on the substitution pattern of the vanillidene double bond of the substrate, either dilactones, dihydrobenzo[b]furans or biphenyls are formed.

The laccase-catalyzed reaction between catechols and thiols using aerial oxygen as the oxidant delivers the corresponding catechol thioethers with yields up to 96% under mild reaction conditions.