A human stem cell–based microrobot system for knee cartilage regeneration was designed with consideration of clinical trials.

Microrobots that can be precisely guided to target lesions have been studied for in vivo medical applications. However, existing microrobots have challenges in vivo such as biocompatibility, biodegradability, actuation module, and intra- and postoperative imaging. This study reports microrobots visualized with real-time x-ray and magnetic resonance imaging (MRI) that can be magnetically guided to tumor feeding vessels for transcatheter liver chemoembolization in vivo. The microrobots, composed of a hydrogel-enveloped porous structure and magnetic nanoparticles, enable targeted delivery of therapeutic and imaging agents via magnetic guidance from the actuation module under real-time x-ray imaging. In addition, the microrobots can be tracked using MRI as postoperative imaging and then slowly degrade over time. The in vivo validation of microrobot system–mediated chemoembolization was demonstrated in a rat liver with a tumor model. The proposed microrobot provides an advanced medical robotic platform that can overcome the limitations of existing microrobots and current liver chemoembolization.

Toward wireless medical microrobot applications driven by an electromagnetic actuation (EMA) system, challenges associated with movability, the electromagnetic force, and the coil system size must be addressed. This paper presents an enhanced EMA system with a higher magnetic field via new coil configurations, an independent magnetic field control method, and application to the multi-degree-of-freedom (DOF) motion of an untethered capsule endoscope. The magnetically actuated capsule endoscope (MACE) system proposed herein consists of an endoscopic capsule with a permanent magnet in the body, eight air-cored stationary electromagnetic coils, and a control system. The coil system is designed to maximize the working space available within a limited equipment space. The MACE is designed to perform full 5-DOF motion, including 3-DOF translation and 2-DOF rotation. The independent magnetic field control method with the new coil configuration enables orientation-independent-driving (OID) control of the capsule endoscope that could not be accomplished by previous EMA systems. The developed system performance was verified by simulations and experiments. The MACE motion in the spatial domain was evaluated with a robotic endoscopic procedure and diagnostic performance by in-vitro and ex-vivo experiments.