Background: Thriassion Plain is considered the most industrialized area in Greece and thus a place where emissions of pollutants are expected to be elevated, leading to the degradation of air quality. Methods: Simultaneous determination of polycyclic aromatic hydrocarbons (PAHs), polychlorinated dibenzo-p-dioxins/dibenzofurans (PCDD/Fs), and polychlorinated biphenyls (PCBs) was performed in PM10 samples. SPSS statistical package was employed for statistical analysis and source apportionment purposes. Cancer risk was estimated from total persistent organic pollutants’ (POPs) dataset according to the available literature. Results: POPs concentrations in particulate matter were measured in similar levels compared to other studies in Greece and worldwide, with mean concentrations of ΣPAHs, ΣPCDD/Fs, dioxin like PCBs, and indicator PCBs being 7.07 ng m⁻³, 479 fg m⁻³, 1634 fg m⁻³, and 18.1 pg m⁻³, respectively. Seasonal variations were observed only for PAHS with higher concentrations during cold period. MDRs, D/F ratios, and principal component analysis (PCA) highlighted combustions as the main source of POPs’ emissions. Estimation of particles’ carcinogenic and mutagenic potential indicates the increased toxicity of PM10 during cold periods, and cancer risk assessment concludes that 3 to 4 people out of 100,000 may suffer from cancer due to POPs’ inhalation. Conclusions: Increased cancer risk for citizens leads to the necessity of chronic POPs’ monitoring in Thriassion Plain, and such strategies have to be a priority for Greek environmental authorities.

A new sensitive and selective gas chromatography tandem mass spectrometry (GC-MS/MS) method was developed for the analysis of 26 polycyclic aromatic hydrocarbons (PAHs), including 16 Environmental Protection Agency (EPA) and 15 + 1 European Union (EU) PAHs, in mussel samples from aquaculture farms in Thermaikos and Strymonian Gulf, Central Macedonia Region, in three sampling periods. Concentrations were found at moderate to low values at all sampling sites, without exceeding maximum levels set by EU. Low molecular weight PAHs were predominant in all samples. Seasonal variation of the concentrations was observed; values were slightly higher in the winter period. Use of diagnostic ratios for potential sources of PAHs showed both petrogenic and pyrolitic origin. In comparison to other related studies of mussels from the Mediterranean Sea, Greek mussels cultivated in the studied gulfs are low in contaminants due to minimal environmental pollution effects. Low concentrations of PAHs are in compliance with the low values of other POPs which were found in the mussels.