This study tackles interobserver variability with respect to specialty training in manual segmentation of non-small cell lung cancer (NSCLC). Four readers included for segmentation are: a data scientist (BY), a medical student (LS), a radiology trainee (MH), and a specialty-trained radiologist (SK) for a total of 293 patients from two publicly available databases. Sørensen–Dice (SD) coefficients and low rank Pearson correlation coefficients (CC) of 429 radiomics were calculated to assess interobserver variability. Cox proportional hazard (CPH) models and Kaplan-Meier (KM) curves of overall survival (OS) prediction for each dataset were also generated. SD and CC for segmentations demonstrated high similarities, yielding, SD: 0.79 and CC: 0.92 (BY-SK), SD: 0.81 and CC: 0.83 (LS-SK), and SD: 0.84 and CC: 0.91 (MH-SK) in average for both databases, respectively. OS through the maximal CPH model for the two datasets yielded c-statistics of 0.7 (95% CI) and 0.69 (95% CI), while adding radiomic and clinical variables (sex, stage/morphological status, and histology) together. KM curves also showed significant discrimination between high- and low-risk patients (p-value < 0.005). This supports that readers’ level of training and clinical experience may not significantly influence the ability to extract accurate radiomic features for NSCLC on CT. This potentially allows flexibility in the training required to produce robust prognostic imaging biomarkers for potential clinical translation.

Early diagnosis of breast cancer unequivocally improves the survival rate of patients and is crucial for disease treatment. With the current developments in infrared imaging, breast screening using dynamic thermography seems to be a great complementary method for clinical breast examination (CBE) prior to mammography. In this study, we propose a sparse deep convolutional autoencoder model named SPAER to extract low-dimensional deep thermomics to aid breast cancer diagnosis. The model receives multichannel, low-rank, approximated thermal bases as input images. SPAER provides a solution for high-dimensional deep learning features and selects the predominant basis matrix using matrix factorization techniques. The model has been evaluated using five state-of-the-art matrix factorization methods and 208 thermal breast cancer screening cases. The best accuracy was for non-negative matrix factorization (NMF)-SPAER + Clinical and NMF-SPAER for maintaining thermal heterogeneity, leading to finding symptomatic cases with accuracies of 78.2% (74.3–82.5%) and 77.7% (70.9–82.1%), respectively. SPAER showed significant robustness when tested for additive Gaussian noise cases (3–20% noise), evaluated by the signal-to-noise ratio (SNR). The results suggest high performance of SPAER for preserveing thermal heterogeneity, and it can be used as a noninvasive in vivo tool aiding CBE in the early detection of breast cancer.

We evaluate radiomic phenotypes derived from CT scans as early predictors of overall survival (OS) after chemoradiation in stage III primary lung adenocarcinoma. We retrospectively analyzed 110 thoracic CT scans acquired between April 2012−October 2018. Patients received a median radiation dose of 66.6 Gy at 1.8 Gy/fraction delivered with proton (55.5%) and photon (44.5%) beam treatment, as well as concurrent chemotherapy (89%) with carboplatin-based (55.5%) and cisplatin-based (36.4%) doublets. A total of 56 death events were recorded. Using manual tumor segmentations, 107 radiomic features were extracted. Feature harmonization using ComBat was performed to mitigate image heterogeneity due to the presence or lack of intravenous contrast material and variability in CT scanner vendors. A binary radiomic phenotype to predict OS was derived through the unsupervised hierarchical clustering of the first principal components explaining 85% of the variance of the radiomic features. C-scores and likelihood ratio tests (LRT) were used to compare the performance of a baseline Cox model based on ECOG status and age, with a model integrating the radiomic phenotype with such clinical predictors. The model integrating the radiomic phenotype (C-score = 0.69, 95% CI = (0.62, 0.77)) significantly improved ($p<0.005$) upon the baseline model (C-score = 0.65, CI = (0.57, 0.73)). Our results suggest that harmonized radiomic phenotypes can significantly improve OS prediction in stage III NSCLC after chemoradiation.

Thermography has been employed broadly as a corresponding diagnostic instrument in breast cancer diagnosis. Among thermographic techniques, deep neural networks show an unequivocal potential to detect heterogeneous thermal patterns related to vasodilation in breast cancer cases. Such methods are used to extract high-dimensional thermal features, known as deep thermomics. In this study, we applied convex non-negative matrix factorization (convex NMF) to extract three predominant bases of thermal sequences. Then, the data were fed into a sparse autoencoder model, known as SPAER, to extract low-dimensional deep thermomics, which were then used to assist the clinical breast exam (CBE) in breast cancer screening. The application of convex NMF-SPAER, combining clinical and demographic covariates, yielded a result of 79.3% (73.5%, 86.9%); the highest result belonged to NMF-SPAER at 84.9% (79.3%, 88.7%). The proposed approach preserved thermal heterogeneity and led to early detection of breast cancer. It can be used as a noninvasive tool aiding CBE.