Cyberknife radiosurgery is a frameless stereotactic robotic radiosurgery which has shown to deliver better treatment outcomes in the treatment of advanced head and neck (H&N) carcinomas, especially in previously irradiated and recurrent cases. The aim of the study was to perform a systematic review of the available data on the outcomes of Cyberknife radiosurgery for treatment of head and neck cancer and to evaluate its collective outcomes. This systematic review was registered with the university with the registration no. FRP/2019/63 and was approved by the Institutional Review Board (RC/IRB/2019/132). Literature search was performed in the following: PubMed, Science direct, SciELO, MyScienceWork, Microsoft Academ EMBASE, Directory of Open Access Journals, and Cochrane databases with the keywords “Cyberknife,” “oral cancer,” “oropharyngeal cancer,” and “head and neck cancer” and data was extracted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The records identified were 147 manuscripts. Excluded articles included 5 duplicate articles, 33 abstracts, 101 full text articles due to being off-topic, case reports, review, non-English, 1 survey, and 2 other articles containing data extracted from a main study which was already included. A total of 5 articles were evaluated for qualitative synthesis. The mean dose of Cyberknife radiosurgery delivered for previously irradiated recurrent H&N carcinoma patients was 34.57 Gy, with a mean sample size of 5 studied during the period of 2000 to 2016. The available evidence from the systematic review indicates that Cyberknife can be an efficacious treatment option for recurrent previously irradiated H&N carcinoma, especially for nonresectable tumors. There is paucity of homogenous data and studies in this arena; hence, meta-analysis could not be performed. Further standardized studies are essential, especially where the treatment of H&N carcinoma is considered.

The Coronavirus Disease 2019(COVID-19) virus testing can be done using multiple specimen types, mainly nasopharyngeal, saliva, and serum. The nasopharyngeal swab (NPS) is a gold standard in COVID-19 testing and diagnosis but is often uncomfortable for the patient and requires professional expertise in sample collection. The rationale of this study was to evaluate saliva, nasopharyngeal, and serum detection of COVID-19 and compare saliva with other specimens in COVID-19 testing. Using PRISMA 2020

The anatomical position of the nasopalatine canal in the anterior maxilla makes it one of the most important vital structures in the region. Surgical and implant procedures in this area require local anesthesia to be administered. It is, therefore, important to morphologically assess the length and shape of the nasopalatine canal for performing surgical procedures with more accuracy in this area. Cone-Beam Computed tomography scans were scrutinized using inclusion criteria of age 18 years and above, absence of any pathological lesions/fracture/surgery in the nasopalatine area, absence of orthodontic treatment or maxillary jaw correction surgeries, and exclusion criteria including CBCT scans with artifacts or error s in the area of interest, anterior implants, absence of bone diseases, trauma, surgeries, and impactions in the area of interest. A total of 360 scans were analyzed for the length and shape of the nasopalatine canals. The results of the study showed that the mean nasopalatine canal length was 12.51 mm. The hourglass shape of the canal was most common and had the highest representation in both genders, with male 80.62% and female 87.01%. A statistically significant difference (p < 0.001) was noted in nasopalatine canal length between males and females. The study provides insight into the significant association of gender with the canal’s shape and length of the canal. The length of the canal does not influence with age. These parameters are helpful for surgical planning and interventions in the anterior maxillary region.

Aim: The purpose of this study is to determine the prevalence and morphological characteristics of the bifid mandibular canal in a Saudi Arabian subpopulation, to aid in preventing surgical complications near the mandibular canal. Patients and Methods: Using CBCT images obtained from the Radiology unit database in a University Hospital Clinics. A total of 488 CBCT images were investigated (244 Female – 178 Male). In the present study, the Naitoh classification was used to categorize the bifid mandibular canal into the following types: 1) Retromolar canal; 2) Dental canal; 3) Forward canal (with or without confluence); and 4) Buccolingual canal. Additional variation (Trifid canal) was included. All CBCTs were assessed in coronal, sagittal, axial, as well as panoramic views using specialized software. Results: The prevalence of BMC was 28.7% (95% CI, 24.5 to 33.2), Gender (p = 0.404) and age (p = 0.654) had no statistical significances, laterality of BMC, patients with unilateral BMC were significantly older than those with bilateral BMC (mean ± SD ages of 40.5 ± 13.5 and 32.9 ± 13.8, respectively, p = 0.009). About two-thirds (67.5%) of the investigated BMC cases were found unilateral. The most common reported type of BMC was retromolar canal. Conclusion: The incidence of bifid mandibular canal using CBCT is considered relatively high in Saudi Arabian subpopulation, with the most common type was the retro-molar canal.

Anterior loop in the mental foramen region is a critical region in the mandible. The non detection of anterior loop leads to inadvertent complications during the surgical procedures in this region. This study aimed to evaluate the morphological assessment of the mental foramen's anterior loop (AL) using (CBCT) cone-beam computed tomography. CBCT data was retrieved from January 2018 to December 2022 and screened for eligibility. Images were viewed using panoramic reconstructed views for initial screening. Further multiplanar reformatted view in axial, coronal and sagittal planes were examined. When anterior loop was detected, the path of inferior alveolar canal was traced and the anterior loop was analyzed. Statistical analysis was carried out on the data. Cross-tabulation was done to associate gender and age with the achieved findings (heights and diameters) using the Chi-square test. In this analysis 519 cases were included and examined for presence of anterior loop. 22 cases were included in the study, out of which 10(45.5%) males and 12(54.5%) females. The prevalence of AL is high among females. AL was found higher on the right side in 14 (68.2%) cases compared to the left side with 7 (31.8%) cases. The mean diameter of AL on the right side was 2.5 mm, and on the left side diameter was 1.96 mm. The prevalence of anterior loop in the region of mental foramen in Saudi Population was found to be 4.24%. Careful evaluation for the anterior loop can prevent hemorrhagic episodes during surgical intervention or implant procedures in the mandibular premolar region.