Nanotechnology could greatly improve global agricultural food production. Chlorantraniliprole and lambda cyhalothrin double-loaded nano-microcapsules were fabricated to enhance the control of pests by pesticides and improve the pesticide utilization efficiency. The nano-microcapsules were synthesized using a method involving the solid in oil in water encapsulation technique and solvent evaporation. The nano-microcapsules slowly and simultaneously released lambda cyhalothrin and chlorantraniliprole. The cumulative lambda cyhalothrin and chlorantraniliprole release rates at 40 h were 80% and 70%, respectively. Indoor Spodoptera frugiperda control tests indicated that the double-loaded nano-microcapsules were more toxic than lambda cyhalothrin water-dispersible granules, chlorantraniliprole water-dispersible granules, and a mixture of lambda cyhalothrin water-dispersible granules and chlorantraniliprole water-dispersible granules, indicating that the pesticides in the nano-microcapsules synergistically controlled Spodoptera frugiperda. The results indicated that pesticide nano-microcapsules with synergistic effects can be developed that can improve the effective pesticide utilization efficiency and pesticide bioavailability. This is a new idea for achieving environmentally intelligent pesticide delivery.