The first lockdown due to COVID-19 in the year 2020 created a particular scenario that forced a change to telework among diverse professions and social groups. This article presents the results of research carried out among samples of Polish, Lithuanian and Spanish remote workers concerning working conditions in organizations and at home, and the potential impact of some professional hazards from home-based telework. On the contrary to earlier published papers on pandemic-induced telework that focused on how the limitations at home of first-time remote workers impacted on their well-being and work–family balance, our research contributes to a more recent endeavor that focuses the analysis on the work design perspective. The results of the survey indicate that employees felt more stressed and in conflict at their remote workstations when they had to telework during the lockdown, and that this negative output was significantly related to the deterioration of some working dimensions like space, quality and design but not to the perception of professional hazards from home-based telework. According to our research, the forced situation seemed not to be a favorable factor for implementing changes in light of the insufficient technical and organizational preparation of employers as well as the employees’ mental preparation. It should be necessary to update sequentially the results of the epidemic-induced telework and conduct research for various stages of the pandemic and the subsequent economic recovery. This could help popularize remote work as one of the tools of the labor market in the future and as a tool for treating labor resources as an element of sustainable development.

After COVID-19, the dynamics of home office development slowed down. According to the experiences of major companies, the problem is “fluctuating”. Research from the pandemic era covers various aspects and fails to present the concept of synthetic developmental conditions. Therefore, the issue of extending the organisation to home spaces was undertaken, identifying the determinants of the sustainable development of workplaces and organisations. The key is to create sustainable work systems, i.e., adapted to the environment, while being creative, critical, and productive. This study aims to establish the cultural determinants of home office development based on empirical research from the perspective of neo-institutionalism. For this purpose, the institutional logics were subject to operationalisation and the co-dependencies of metalogics with the types of organisational cultures assumed in the Cameron–Quinn OCAI model were established. The information was collected in a CAWI survey. The presented research procedure constitutes a methodical innovation. The results demonstrate a trend of changes in the dominating types of organisational culture from market control to cooperation and creation with a stimulating role of professional logics (occupation, organisation) from the perspective of working from home which brings sustainable management and business models. There is a subtle role of home logic and low employee readiness level. The adapted cultural approach demonstrates that increasing effectiveness of home office solutions requires development of integrated practices, which consider this type of work as separate and specialised. The past corporate failures and spontaneous methods cannot serve as grounds for strategies (long-term solutions). However, the research demonstrates a low level and limited range of employee impact on the organisational culture. It also indicates the need for additional analyses to determine the concept of designing workplaces in the Sustainability–Harmonisation trajectory.