Automatic sleep stage mymargin classification is of great importance to measure sleep quality. In this paper, we propose a novel attention-based deep learning architecture called AttnSleep to classify sleep stages using single channel EEG signals. This architecture starts with the feature extraction module based on multi-resolution convolutional neural network (MRCNN) and adaptive feature recalibration (AFR). The MRCNN can extract low and high frequency features and the AFR is able to improve the quality of the extracted features by modeling the inter-dependencies between the features. The second module is the temporal context encoder (TCE) that leverages a multi-head attention mechanism to capture the temporal dependencies among the extracted features. Particularly, the multi-head attention deploys causal convolutions to model the temporal relations in the input features. We evaluate the performance of our proposed AttnSleep model using three public datasets. The results show that our AttnSleep outperforms state-of-the-art techniques in terms of different evaluation metrics. Our source codes, experimental data, and supplementary materials are available at https://github.com/emadeldeen24/AttnSleep .

For prognostics and health management (PHM) of mechanical systems, a core task is to predict machine remaining useful life (RUL). Currently, deep structures with automatic feature learning, such as long short-term memory (LSTM), have achieved great performances for RUL prediction. However, the conventional LSTM network only uses the learned features at last time step for regression or classification, which is not efficient. Besides, some handcrafted features with domain knowledge may convey additional information for the prediction of RUL. It is thus highly motivated to integrate both those handcrafted features and automatically learned features for RUL prediction. In this paper, we propose an attention based deep learning framework for machine RUL prediction. The LSTM network is employed to learn sequential features from raw sensory data. Meanwhile, the proposed attention mechanism is able to learn the importance of features and time steps, and assign larger weights to more important ones. Moreover, a feature fusion framework is developed to combine the handcrafted features with automatically learned features to boost the performance of RUL prediction. Extensive experiments have been conducted on two real datasets and experimental results demonstrate that our proposed approach outperforms the state-of-the-arts.

Background: How to detect protein complexes is an important and challenging task in post genomic era. As the increasing amount of protein-protein interaction (PPI) data are available, we are able to identify protein complexes from PPI networks. However, most of current studies detect protein complexes based solely on the observation that dense regions in PPI networks may correspond to protein complexes, but fail to consider the inherent organization within protein complexes. Results: To provide insights into the organization of protein complexes, this paper presents a novel core-attachment based method (COACH) which detects protein complexes in two stages. It first detects protein-complex cores as the "hearts" of protein complexes and then includes attachments into these cores to form biologically meaningful structures. We evaluate and analyze our predicted protein complexes from two aspects. First, we perform a comprehensive comparison between our proposed method and existing techniques by comparing the predicted complexes against benchmark complexes. Second, we also validate the core-attachment structures using various biological evidence and knowledge. Conclusion: Our proposed COACH method has been applied on two different yeast PPI networks and the experimental results show that COACH performs significantly better than the state-of-the-art techniques. In addition, the identified complexes with core-attachment structures are demonstrated to match very well with existing biological knowledge and thus provide more insights for future biological study.

Objective: Entropy algorithms have been widely used in analyzing EEG signals during anesthesia. However, a systematic comparison of these entropy algorithms in assessing anesthesia drugs’ effect is lacking. In this study, we compare the capability of twelve entropy indices for monitoring depth of anesthesia (DoA) and detecting the burst suppression pattern (BSP), in anesthesia induced by GA-BAergic agents. Methods: Twelve indices were investigated, namely Response Entropy (RE) and State entropy (SE), three wavelet entropy (WE) measures (Shannon WE (SWE), Tsallis WE (TWE) and Renyi WE (RWE)), Hilbert-Huang spectral entropy (HHSE), approximate entropy (ApEn), sample entropy (SampEn), Fuzzy entropy, and three permutation entropy (PE) measures (Shannon PE (SPE), Tsallis PE (TPE) and Renyi PE (RPE)). Two EEG data sets from sevoflurane-induced and isoflu-rane-induced anesthesia respectively were selected to assess the capability of each entropy index in DoA monitoring and BSP detection. To validate the effectiveness of these entropy algorithms, phar-macokinetic / pharmacodynamic (PK/PD) modeling and prediction probability analysis were applied. The multifractal detrended fluctuation analysis (MDFA) as a non-entropy measure was compared. Results: All the entropy and MDFA indices could track the changes in EEG pattern during different anesthesia states. Three PE measures outperformed the other entropy indices, with less baseline vari-ability, higher coefficient of determination and prediction probability, and RPE performed best; ApEn and SampEn discriminated BSP best. Additionally, these entropy measures showed an ad-vantage in computation efficiency compared with MDFA. Conclusion: Each entropy index has its advantages and disadvantages in estimating DoA. Overall, it is suggested that the RPE index was a superior measure. Significance: Investigating the advantages and disadvantages of these entropy indices could help improve current clinical indices for monitoring DoA.