To evaluate the status of psychological resilience among women in their second pregnancy and to investigate the possible influencing factors. A total of 275 women in their second pregnancy and who met the criteria were surveyed from two public hospitals in China from July 2018 to January 2019. The instruments included the General Self-designed Questionnaire, Connor and Davidson Resilience Scale, Social Support Rate Scale, and 36-Item Pregnancy Stress Rating Scale. The total psychological resilience score of second-pregnancy women was relatively low. Multivariate regression analysis identified five factors associated with psychological resilience: intimacy with husband, social support utilization, gender of the first child, high-risk pregnancy of the first child, and the stress caused by worrying about the health and safety of mother and fetus. Women in their second pregnancy represent a unique population, and their low psychological resilience score deserves attention. Identification of factors contributing to the decreased psychological resilience may enable us to design prevention and intervention strategies and to deliver specific psychological supports to pregnant women at high risk of developing negative psychology.