Chang Won Kho Ph.D Chang Won has been an Assistant Professor of the School of Korean Medicine at Pusan National University, Korea, since 2020. In the last decade, his research has been focused on identifying and characterizing novel molecular pathways in heart failure. One area of particular interest to him is the role of post-translational modification of key proteins involved in cardiac dysfunction. He designed a multi-faceted approach to profile proteins in cardiomyocytes that interact with sarcoplasmic reticulum calcium ATPase (SERCA2a) pump. His efforts have led to the identification of Small Ubiquitin-like Modifier type 1 (SUMO1) as a potentially important target for heart failure therapy. Current research projects of his group as follows: • Identifying SUMO1 modified proteome under physiological and pathological conditions. • Understanding the regulation of SUMO1 by microRNAs in the heart. • Characterizing the relationship of post-translational acetylation of SERCA2a and their potential as new molecular pathway underpinning physiological dysfunction and heart failure. • Defining the role of SUMO1 in Duchenne Muscular Dystrophy. This research aims to validate the SUMO pathway and its potential therapeutic target for heart failure.