Alexander S. Spiro

Dr. Alexander S. Spiro


Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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21 November 2012 in Archives of orthopaedic and trauma surgery
Verified
Journal Article
Closed access
PDF file
JKJ. P. Kolb
J. P. Kolb
ASArndt Schilling
Arndt Schilling
JBJ. Bischoff
J. Bischoff
AOA. Novo de Oliveira
A. Novo de Oliveira
ASAlexander S. Spiro
Alexander S. Spiro
WLW. Lehmann
W. Lehmann

14 June 2018 in Acta Orthopaedica
Verified
Journal Article
Open access
NSNorbert Stiel
Norbert Stiel
KBKornelia Babin
Kornelia Babin
EVEik Vettorazzi
Eik Vettorazzi
SBSandra Breyer
Sandra Breyer
NENicola Ebert
Nicola Ebert
ASAlexander S. Spiro
Alexander S. Spiro
Background and purpose — Fixed knee flexion deformity in children is a common problem in various diseases including myelomeningocele and cerebral palsy. Until now, only a few studies focusing on the surgical procedure of anterior distal femoral hemiepiphysiodesis have been published. We analyzed outcome and correction rate in the largest case series to date of patients treated by staples or 8-plates. Patients and methods — We reviewed the medical records of all patients with fixed knee flexion deformity who were treated with anterior distal femoral hemiepiphysiodesis using either staples or 8-plates between the years 2002 and 2017 (73 patients; 130 knees). 49 patients (83 knees) had completed treatment with implant removal at the time of full correction of the deformity or at skeletal maturity and were included. The average age at operation was 12 years (6–20). Patients were assigned to 3 different groups based on their diagnosis: cerebral palsy, myelomeningocele, and the “other” group.d Results — Mean fixed knee flexion deformity improved from 21° (10–60°) to 8° (0–50°) (p < 0.001) with an average correction rate of 0.44° per month (range –2.14° to 1.74°). The correction rate per month was lowest for patients with cerebral palsy (0.20°), followed by the myelomeningocele group (0.50°), and the “other” group (0.58°). Implant loosening occurred in 10% of the treated knees with consecutive re-implantation in 5% of the cases. Interpretation — Anterior distal femoral hemiepiphysiodesis is an effective and safe method for the treatment of fixed knee flexion deformity in children. The optimal timing depends on the remaining individual growth potential, the underlying disease, and the extent of the deformity.

14 April 2021 in Diagnostics
Verified
Journal Article
Open access
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SWSebastian Weiss
Sebastian Weiss
AKAlexander Korthaus
Alexander Korthaus
NBNora Baumann
Nora Baumann
JYJin Yamamura
Jin Yamamura
ASAlexander S. Spiro
Alexander S. Spiro
MPMatthias Hubertus Priemel
Matthias Hubertus Priemel
Soft-tissue sarcomas (STS) are a rare subtype of soft-tissue mass and are frequently misinterpreted as benign lesions. Magnetic resonance imaging (MRI) is the primary recommended type of diagnostics. To assess the quality of primary radiology reports, we investigated whether recommended MRI report elements were included in compliance with European Society of Musculoskeletal Radiology (ESSR) guidelines. A total of 1107 patients were evaluated retrospectively, and 126 radiological reports on patients with malignant STS were assessed for ESSR quality criteria. One or more required sequences or planes were missing in 67% of the reports. In all 126 cases, the report recognized the mass as anomalous (100%). Sixty-eight percent of the reports mentioned signs of malignancy. The majority of reports (n = 109, 87%) articulated a suspected diagnosis, 32 of which showed a mismatch with the final diagnosis (25%). Thirty-two percent of the reports had a misinterpretation of the masses as benign. Benign misinterpretations were more common in masses smaller than 5 cm (65% vs. 27%). Thirty percent of the reports suggested tissue biopsy and 6% recommended referral to a sarcoma center. MRI reports showed frequent deviations from ESSR guidelines, and protocol guidelines were not routinely met. Deviations from standard protocol and reporting guidelines could put patients at risk for inadequate therapy.

5 November 2021 in Children
Verified
Journal Article
Open access
PDF file
JRJulien Roß
Julien Roß
IFIvan Foeldvari
Ivan Foeldvari
KKKara Krajewski
Kara Krajewski
SBSebastian Butscheidt
Sebastian Butscheidt
FBFrank Timo Beil
Frank Timo Beil
ASAlexander S. Spiro
Alexander S. Spiro
Background: This study aimed to determine the clinical and radiological course in children who had Legg–Calvé–Perthes disease (LCPD) associated with juvenile idiopathic arthritis (JIA). Methods: In a retrospective chart review between 2007 and 2019, eight consecutive JIA patients diagnosed with concomitant LCPD were identified and compared with a case-control group of 10 children with LCPD only. Results: LCPD was diagnosed at a mean age of 8.1 years (3.0–14.7) in children with JIA as compared to 6.1 years (2.9–10.0) in controls. According to the modified Harris Hip Score (mHHS), four children with JIA and all controls had an excellent result. Regarding the fragmentation severity and the duration of each stage, we found no differences using the lateral pillar and modified Elizabethtown classification. Five hips were classified as Stulberg I/II, two hips as Stulberg III, and one hip as Stulberg V with no evidence of hip dysplasia or severe overcoverage in either group. Conclusions: The radiological outcome of LCPD did not differ between both groups, while the clinical outcome was slightly better in controls. Physicians should be aware that children with LCPD may have JIA too. In suspicious cases, further investigations are recommended, and patients should be referred to pediatric rheumatologists.