Virological response to antiretroviral therapy (ART) remains a challenge for HIV-infected children and adolescents due to non-optimization of pediatric ART for resource-limited settings. In this study, we aimed to investigate factors associated with virologic failure (VF) in HIV-infected-children and adolescents on ART in Cameroon. A prospective patient-based cohort study was conducted among HIV-infected children (0–9 years) and adolescents (10–19 years) followed-up between November 2018 and October 2019 in 38 healthcare centers located in the Littoral region of Cameroon. The 1^st viral load (VL) was assessed after 6 months of ART initiation and the 2^nd VL between 3 and 6 six months later in patients with VL ≥1000 copies/ml in accordance with the national algorithm using Abbott Real-Time HIV-1 Viral Load Assay. Multivariate analyses were performed to identify the determinants of higher risk of VF. Of 1,029 HIV-infected children and adolescents (393 children and 636 adolescents), 801 (77.8%) cumulatively presented with VL <1000 copies/mL within 12 months on ART. Adolescents were more likely to have VF than children (24.5% vs 18.3%, OR: 1.39; 95%CI: 1.00–1.93; p = 0.047). Patients followed-up in decentralized care units were significantly more likely to have VF compared to those attending the accredited treatment centers (26.1% vs 16.6%, OR: 1.88, 95%CI: 1.37–2.58; p<0.001). Our findings show a high rate of VL suppression (VLS, 77.8%) among HIV-infected children and adolescents, albeit lower than the established target of 90%. Being adolescent and patients followed in the decentralized care units are high risk factors for VF, thereby necessitating routine therapeutic education of patients and guardians in resource limited countries to improve VLS.

Background: The purpose of this study was to determine the prevalence of Burnout syndrome (BOS), risk factors and the effect of physical activity in six professions in Cameroon. Methods: 2012 participants completed questionnaires related to socio-demographic conditions and work perception. Appropriate Maslach Burnout Inventory (MBI) psychometers were used for specific professions. Level of physical activity and sports practice was determined using the Ricci and Gagnon scale. Results: The overall prevalence of burnout was 67.9%; with 5.3% high; 34.3% moderate; and 60.4% low degree. 42.2% of victims of BOS were in high loss of personal achievement, 39.9% in high depersonalization of and 38.2% in high emotional exhaustion. Higher prevalence of BOS was found in Army (85.3%) and educational sectors (78.5% in secondary school teachers (SET) and 68% in university teaching staff (UTS)). BOS was significantly associated (p < 0.05) with distance from home to workplace, number of children per participant, number of hospitals attended, number of guards per month, labour hours per day, conflicts with the hierarchy, conflicts with colleagues, poor working conditions, unsatisfactory salary, part time teaching in private university institutions, job seniority, sedentariness. Apart from UTS, no association was observed between the level of physical activity and occurrence of BOS. Conclusion: Burnout is a reality in occupational environments in Cameroon.

The aim of this study was to assess the epidemiology of musculoskeletal disorders (MSDs) among the teaching staff of the University of Douala and determine their association with physical activity (PA) practice. The Nordic questionnaire was used to assess MSDs. Ricci–Gagnon questionnaire was used to determine the level of PA. We recruited 104 participants mean-aged 42 ± 8 years, 80% male. Previous 7 days and 12 months prevalence were 56.7% and 80.8%, respectively. The most affected body regions were neck, shoulders and lower back. No significant association was found between MSDs and PA. Celibacy was significantly associated with previous 7-days MSDs (p = 0.048) while age ≥ 45 years and job seniority ≥ 10 years were significantly associated with a reduced risk of previous 12-months MSDs (p = 0.039 and p = 0.016, respectively). The prevalence of MSDs among university of Douala teaching staff showed no significant effect with the practice of PA.

Background: Heavy schoolbag is known to cause health problems for school children. The aim of this study was to determine the effects of carrying heavy schoolbags on the musculoskeletal pain among primary school children of the two subsystems in Yaounde, Cameroon. Methods: A cross-sectional study was carried out in primary schools in Yaounde. A total of 457 school-children (8.2 ± 2.2 years) were included, 202 from the French-speaking subsystem, and 255 from the English-speaking subsystem. Parameters studied included weight, height, and schoolbag weight. A questionnaire was used to collect socio-demographic information and potential musculoskeletal pain in three regions: back, shoulders, and neck. Results: The mean weight of children and their bags was 28.4 ± 8.2 kg and 5.2 ± 2.3 kg respectively. More than 50% of schoolchildren in the two subsystems carried a schoolbag weighing more than 15% of body weight. The back (38%) was the least affected area in comparison to the shoulders (58.6%) and neck (42.4%) (p < 0.001). Carrying heavy bags and walking to school was associated with pain in the back, shoulders, and neck. School-children in the French-speaking subsystem had lower risk (adjusted Odds Ratio 0.438, 95% CI = 0.295-0.651; p < 0.001) to develop a sore neck compared to peers from the English-speaking subsystem. Conclusion: Carrying heavy schoolbags is associated to musculoskeletal pain in schoolchildren. The means moving to and from school is a main risk factor of developing musculoskeletal pain. French-speaking schoolchildren develop less neck pain than English-speaking schoolchildren.

Background: Musculoskeletal pains (MSPs) in sport are cause of poor performances and loss of competition in athletes. The present study aimed at determining the prevalence of MSPs with regard to sport disciplines and athletic status. Methods: A cross-sectional study was conducted among 320 Senegalese professional and amateur athletes practicing football, basketball, rugby, tennis, athletics, and wrestling. Rates of MSPs in the past year (MSPs-12) and week (MSPs-7d) were assessed using standard questionnaires. Results: Overall proportions of MSPs-12 and MSPs-7d were 70 and 74.2%, respectively. MSPs-12 were more frequently reported on shoulders (40.6%), neck (37.1%) and hips/thigh (34.4%), while MSPs-7d were predominant on hips/thigh (29.5%), shoulders (25.7%), and upper back (17.2%). Proportions of MSPs-12 and MSPs-7d varied significantly by sport disciplines, with highest values among basketball players. Again, highest MSPs-12 proportions on shoulders (29.7%, P = 0.02), wrists/hands (34.6%, P = 0.001), (40.2%, P = 0.0002), and knees (38.8%, P = 0.002) were seen among basketball players. High proportions of MSPs-7d were seen on shoulders (29.6%, P = 0.04) for tennis players, wrists/hands (29.4%, P = 0.03) for basketball and football players, and hips/thigh (38.8%, P < 0.00001) for basketball players. Football players had reduced risk of MSPs-12 by 75% on lower back (OR = 0.25; 95% CI. 0.10—0.63; P = 0.003) and by 72% on knees (OR = 0.28; 95% CI. 0.08—0. 95; P = 0.04). In contrast, tennis players were more at risk of MSPs-12 on shoulders (OR = 3.14; 95% CI. 1.14–8.68; P = 0.02), wrists/hands (OR = 5.18; 95% CI.1.40–11.13; P = 0.01), and hips/thigh (OR = 2.90; 95% CI. 1.1–8.38; P = 0.04). Professionals were protected from MSPs-12 on neck pain with a significant reduction of risk by 61% (OR = 0.39, 95% CI. 0.21–0.75, P = 0.03). Conclusion: MSPs are a reality among athletes and their risk is modulated by sport disciplines, athletic status and gender.