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COVID-19 is a highly infectious respiratory disease which leads to several clinical conditions related to the dysfunction of the respiratory system along with other physical and psychological complaints. Severely affected patients are referred to intensive care units (ICUs), limiting their possibilities for physical exercise. Whole body vibration (WBV) exercise is a non-invasive, physical therapy, that has been suggested as part of the procedures involved with pulmonary rehabilitation, even in ICU settings. Therefore, in the current review, the World Association of Vibration Exercise Experts (WAVEX) reviewed the potential of WBV exercise as a useful and safe intervention for the management of infected individuals with COVID-19 by mitigating the inactivity-related declines in physical condition and reducing the time in ICU. Recommendations regarding the reduction of fatigue and the risk of dyspnea, the improvement of the inflammatory and redox status favoring cellular homeostasis and the overall improvement in the quality of life are provided. Finally, practical applications for the use of this paradigm leading to a better prognosis in bed bound and ICU-bound subjects is proposed.
Borja Sañudo; Adérito Seixas; Rainer Gloeckl; Jörn Rittweger; Rainer Rawer; Redha Taiar; Eddy A. Van Der Zee; Marieke J.G. Van Heuvelen; Ana Cristina Lacerda; Alessandro Sartorio; Michael Bemben; Darryl Cochrane; Trentham Furness; Danúbia De Sá-Caputo; Mario Bernardo-Filho. Potential Application of Whole Body Vibration Exercise for Improving the Clinical Conditions of COVID-19 Infected Individuals: A Narrative Review from the World Association of Vibration Exercise Experts (WAVex) Panel. International Journal of Environmental Research and Public Health 2020, 17, 3650 .
AMA StyleBorja Sañudo, Adérito Seixas, Rainer Gloeckl, Jörn Rittweger, Rainer Rawer, Redha Taiar, Eddy A. Van Der Zee, Marieke J.G. Van Heuvelen, Ana Cristina Lacerda, Alessandro Sartorio, Michael Bemben, Darryl Cochrane, Trentham Furness, Danúbia De Sá-Caputo, Mario Bernardo-Filho. Potential Application of Whole Body Vibration Exercise for Improving the Clinical Conditions of COVID-19 Infected Individuals: A Narrative Review from the World Association of Vibration Exercise Experts (WAVex) Panel. International Journal of Environmental Research and Public Health. 2020; 17 (10):3650.
Chicago/Turabian StyleBorja Sañudo; Adérito Seixas; Rainer Gloeckl; Jörn Rittweger; Rainer Rawer; Redha Taiar; Eddy A. Van Der Zee; Marieke J.G. Van Heuvelen; Ana Cristina Lacerda; Alessandro Sartorio; Michael Bemben; Darryl Cochrane; Trentham Furness; Danúbia De Sá-Caputo; Mario Bernardo-Filho. 2020. "Potential Application of Whole Body Vibration Exercise for Improving the Clinical Conditions of COVID-19 Infected Individuals: A Narrative Review from the World Association of Vibration Exercise Experts (WAVex) Panel." International Journal of Environmental Research and Public Health 17, no. 10: 3650.
Background Potential moderators such as exercise intensity or apolipoprotein-E4 (ApoE4) carriership may determine the magnitude of exercise effects on physical and cognitive functions in patients with dementia (PwD). We determined the effects of a 24-week aerobic and strength training program with a low- and high-intensity phase on physical and cognitive function. Methods In an assessor-blinded randomized trial, 91 PwD (all-cause dementia, recruited from daycare and residential care facilities, age 82.3 ± 7.0 years, 59 women, Mini-Mental State Examination 20.2 ± 4.4) were allocated to the exercise or control group. In the exercise group, PwD participated in a walking and lower limb strength training program with 12 weeks low- and 12 weeks high-intensity training offered three times/week. Attention-matched control participants performed flexibility exercises and recreational activities. We assessed adherence, compliance, and exercise intensity for each session. We assessed physical (endurance, gait speed, mobility, balance, leg strength) and cognitive (verbal memory, visual memory, executive function, inhibitory control, psychomotor speed) functions with performance-based tests at baseline and after 6, 12, 18, 24, and 36 weeks (follow-up). ApoE4 carriership was determined post-intervention. Results Sixty-nine PwD were analyzed. Their mean attendance was ~ 60% during the study period. There were no significant effects of the exercise vs. control intervention on endurance, mobility, balance, and leg strength in favor of the exercise group (Cohen’s d = 0.13–0.18). Gait speed significantly improved with ~ 0.05 m/s after the high-intensity phase for exercise participants (Cohen’s d = 0.41) but declined at follow-up. There were no significant effects of the exercise vs. control intervention on any of the cognitive measures (Cohen’s d ~ − 0.04). ApoE4 carriership did not significantly moderate exercise effects on physical or cognitive function. Conclusions Exercise was superior to control activities for gait speed in our sample of PwD. However, the training effect provided no protection for mobility loss after detraining (follow-up). There were no beneficial effects of the exercise vs. control group on cognitive function. Exercise intensity moderated the effects of exercise on gait speed. ApoE4 carriership moderated the effect of exercise on global cognition only (trend level). Trial registration Netherlands Trial Register, NTR5035. Registered on 2 March 2015.
L. M. J. Sanders; T. Hortobágyi; E. G. A. Karssemeijer; E. A. Van Der Zee; E. J. A. Scherder; M. J. G. Van Heuvelen. Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial. Alzheimer's Research & Therapy 2020, 12, 1 -15.
AMA StyleL. M. J. Sanders, T. Hortobágyi, E. G. A. Karssemeijer, E. A. Van Der Zee, E. J. A. Scherder, M. J. G. Van Heuvelen. Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial. Alzheimer's Research & Therapy. 2020; 12 (1):1-15.
Chicago/Turabian StyleL. M. J. Sanders; T. Hortobágyi; E. G. A. Karssemeijer; E. A. Van Der Zee; E. J. A. Scherder; M. J. G. Van Heuvelen. 2020. "Effects of low- and high-intensity physical exercise on physical and cognitive function in older persons with dementia: a randomized controlled trial." Alzheimer's Research & Therapy 12, no. 1: 1-15.
Dementia affects cognitive functioning, physical functioning, activities of daily living (ADLs), and quality of life (QOL). Pharmacological treatments to manage, cure or prevent dementia remain controversial. Therefore development of non-pharmacological approaches to prevent, or at least delay the onset and progression of dementia is urgently needed. Passive exercise is proposed to be such a non-pharmacological alternative. This study primarily aims to investigate the effects of three different forms of passive exercise on QOL and ADLs of institutionalized patients with dementia. The secondary aims are to assess the effects of three different forms of passive exercise on cognitive functioning and physical functioning of institutionalized patients with dementia as well as on care burden of both the primary formal and primary informal caregivers of these patients. This is a multicenter randomized controlled trial. Three forms of passive exercise are distinguished; motion simulation (MSim), whole body vibration (WBV), and a combination of both MSim + WBV. Intervention effects are compared to a control group receiving regular care. Institutionalized patients with dementia follow a six-week intervention program consisting of four 4-12 min sessions a week. The primary outcome measures QOL and ADLs and secondary outcome measure care burden are assessed with questionnaires filled in by the primary formal and informal caregivers of the patient. The other secondary outcome measures cognitive and physical functioning are assessed by individual testing. The four groups are compared at baseline, after 6 weeks of intervention, and 2 weeks after the intervention has ended. This study will provide insight in the effects of different forms of passive exercise on QOL, ADLs, cognitive and physical functioning and care burden of institutionalized patients with dementia and their primary formal and informal caregivers. The results of this study might support the idea that passive exercise can be an efficient alternative for physical activity for patients not able to be or stay involved in active physical exercise. The Netherlands National Trial Register ( NTR6290 ). Retrospectively registered 29 March 2017.
Marelle Heesterbeek; Eddy A. Van Der Zee; Marieke J. G. Van Heuvelen. Passive exercise to improve quality of life, activities of daily living, care burden and cognitive functioning in institutionalized older adults with dementia - a randomized controlled trial study protocol. BMC Geriatrics 2018, 18, 182 .
AMA StyleMarelle Heesterbeek, Eddy A. Van Der Zee, Marieke J. G. Van Heuvelen. Passive exercise to improve quality of life, activities of daily living, care burden and cognitive functioning in institutionalized older adults with dementia - a randomized controlled trial study protocol. BMC Geriatrics. 2018; 18 (1):182.
Chicago/Turabian StyleMarelle Heesterbeek; Eddy A. Van Der Zee; Marieke J. G. Van Heuvelen. 2018. "Passive exercise to improve quality of life, activities of daily living, care burden and cognitive functioning in institutionalized older adults with dementia - a randomized controlled trial study protocol." BMC Geriatrics 18, no. 1: 182.
Purpose: Physical activity (PA) has the potential to slow the progression of dementia patients' cognitive and physical decline. A better understanding of the factors that facilitate or hamper dementia patients' PA participation will increase the success rate of implementing PA in dementia patients' daily care. We systematically screened the barriers, motivators, and facilitators of PA participation in dementia patients, complementing previous analyses of quantitative correlates of PA in community-dwelling dementia patients. Methods: Systematic searches yielded 78 potential studies of which seven met the eligibility criteria including 39 dementia patients and 36 caregivers (33 spouses and three daughters). Results: We identified 35 barriers, 26 motivators, and 21 facilitators related to PA. We reduced these factors to six themes within the social-ecological model. Prominent barriers to PA were physical and mental limitations and difficulties with guidance and organization of PA by caregivers. Motivators included the motivation to maintain physical and mental health and participate in preferred PA options. Facilitators included strategies to avoid health problems, providing support and guidance for PA, and access to convenient and personalized PA options. Conclusions: The emerging picture suggests that dementia patients' PA participation will increase if service providers become familiar with the health benefits of PA, the characteristics of PA programs, methods of delivery, and the concepts of how such programs can be personalized to and synchronized with patients' individual needs. (C) 2016 Elsevier Ireland Ltd. All rights reserved
Helena J.M. van Alphen; Tibor Hortobágyi; Marieke J.G. van Heuvelen. Barriers, motivators, and facilitators of physical activity in dementia patients: A systematic review. Archives of Gerontology and Geriatrics 2016, 66, 109 -118.
AMA StyleHelena J.M. van Alphen, Tibor Hortobágyi, Marieke J.G. van Heuvelen. Barriers, motivators, and facilitators of physical activity in dementia patients: A systematic review. Archives of Gerontology and Geriatrics. 2016; 66 ():109-118.
Chicago/Turabian StyleHelena J.M. van Alphen; Tibor Hortobágyi; Marieke J.G. van Heuvelen. 2016. "Barriers, motivators, and facilitators of physical activity in dementia patients: A systematic review." Archives of Gerontology and Geriatrics 66, no. : 109-118.
Self-reported data suggest that older adults with dementia are inactive. The purpose of the present study was to objectively assess the physical activity (PA) levels of community-dwelling and institutionalized ambulatory patients with dementia, and to compare with the PA levels of cognitive healthy older adults. We used actigraphy to assess the PA levels in institutionalized (n = 83, age: 83.0 ± 7.6, Mini-Mental-State Examination (MMSE): 15.5 ± 6.5) and community-dwelling dementia patients (n = 37, age: 77.3 ± 5.6, MMSE-score: 20.8 ± 4.8), and healthy older adults (n = 26, age: 79.5 ± 5.6, MMSE-score: 28.2 ± 1.6). We characterized PA levels based on the raw data and classified <100 counts/min as sedentary behavior. Institutionalized dementia patients had the lowest daily PA levels (1.69 ± 1.33 counts/day), spent 72.1% of the day sedentary, and were most active between 8:00 and 9:00 am. Institutionalized vs. community-dwelling dementia patients had 23.5% lower daily PA levels (difference M = 0.52, p = .004) and spent 9.3% longer in sedentariness (difference M = 1.47, p = .032). Community-dwelling dementia patients spent 66.0% of the day sedentary and were most active between 9:00 to 10:00 am with a second peak between 14:00 to 15:00. Community-dwelling dementia patients vs healthy older adults’ daily PA levels and sedentary time were 21.6% lower and 8.9% longer, respectively (difference M = 0.61, p = .007; difference M = 1.29, p = .078). Institutionalized and community-dwelling dementia patients are sedentary for most of the day and the little PA they perform is of lower intensity compared to their healthy peers. Their highest PA peak is when they get out of bed in the morning. In addition, it seems that institutionalized living is associated with lower PA levels in dementia patients. These are the first results that objectively characterize institutionalized as well as community-dwelling dementia patients’ PA levels and confirm that dementia patients are inactive.
Helena van Alphen; Karin M. Volkers; Christiaan G. Blankevoort; Erik J. A. Scherder; Tibor Hortobágyi; Marieke J. G. Van Heuvelen. Older Adults with Dementia Are Sedentary for Most of the Day. PLOS ONE 2016, 11, e0152457 .
AMA StyleHelena van Alphen, Karin M. Volkers, Christiaan G. Blankevoort, Erik J. A. Scherder, Tibor Hortobágyi, Marieke J. G. Van Heuvelen. Older Adults with Dementia Are Sedentary for Most of the Day. PLOS ONE. 2016; 11 (3):e0152457.
Chicago/Turabian StyleHelena van Alphen; Karin M. Volkers; Christiaan G. Blankevoort; Erik J. A. Scherder; Tibor Hortobágyi; Marieke J. G. Van Heuvelen. 2016. "Older Adults with Dementia Are Sedentary for Most of the Day." PLOS ONE 11, no. 3: e0152457.
Evidence shows that living in small scale homelike Special Care Units (SCU) has positive effects on behavioural and psychological symptoms of patients with dementia. Effects on cognitive functioning in relation to care facilities, however, are scarcely investigated. The purpose of this study is to gain more insight into the effects of living in small scale homelike Special Care Units, compared to regular SCU's, on the course of cognitive functioning in dementia. A group of 67 patients with dementia who moved from a regular SCU to a small scale homelike SCU and a group of 48 patients with dementia who stayed in a regular SCU participated in the study. Cognitive and behavioural functioning was assessed by means of a neuropsychological test battery and observation scales one month before (baseline), as well as 3 (post) and 6 months (follow-up) after relocation. Comparing the post and follow-up measurement with the baseline measurement, no significant differences on separate measures of cognitive functioning between both groups were found. Additional analyses, however, on 'domain clusters' revealed that global cognitive functioning of the small scale homelike SCU group showed significantly less cognitive decline three months after the transfer (p < 0.05). Effect sizes (95% CI) show a tendency for better aspects of cognition in favour of the homelike small scaled SCU group, i.e., visual memory, picture recognition, cognitive decline as observed by representatives and the clustered domains episodic memory and global cognitive functioning. While there is no significant longitudinal effect on the progression of cognitive decline comparing small scaled homelike SCU's with regular SCU's for patients with dementia, analyses on the domain clusters and effect sizes cautiously suggest differences in favour of the small scaled homelike SCU for different aspects of cognition.
Jeroen S. Kok; Marieke J. G. Van Heuvelen; Ina J. Berg; Erik J. A. Scherder. Small scale homelike special care units and traditional special care units: effects on cognition in dementia; a longitudinal controlled intervention study. BMC Geriatrics 2016, 16, 47 .
AMA StyleJeroen S. Kok, Marieke J. G. Van Heuvelen, Ina J. Berg, Erik J. A. Scherder. Small scale homelike special care units and traditional special care units: effects on cognition in dementia; a longitudinal controlled intervention study. BMC Geriatrics. 2016; 16 (1):47.
Chicago/Turabian StyleJeroen S. Kok; Marieke J. G. Van Heuvelen; Ina J. Berg; Erik J. A. Scherder. 2016. "Small scale homelike special care units and traditional special care units: effects on cognition in dementia; a longitudinal controlled intervention study." BMC Geriatrics 16, no. 1: 47.
To compare training and follow-up effects of combined aerobic and strength training versus aerobic-only training on cognitive and motor function in institutionalized patients with dementia and to explore whether improved motor function mediates improved cognitive function.Using a 9-week, parallel, three-group, single-blind, randomized, controlled trial with a follow-up assessment at week 18, we assessed 109 patients with dementia (age 85.5 ± 5.1 years) in a psycho-geriatric nursing home. Each 9-week intervention consisted of 36, 30-minute sessions. A combined group (N = 37) received and completed two strength and two walking sessions per week, an aerobic group (N = 36) completed four walking sessions, and a social group (N = 36) completed four social visits per week. Cognitive and motor functions were assessed at baseline, after the 9-week intervention, and after a consecutive 9 weeks of usual care.Baseline corrected post-test scores in the combined versus the social group were higher for global cognition, visual memory, verbal memory, executive function, walking endurance, leg muscle strength, and balance. Aerobic versus social group scores were higher for executive function. Follow-up effects reversed toward baseline values. Motor improvement did not significantly mediate cognitive improvement.Compared with a nonexercise control group, a combination of aerobic and strength training is more effective than aerobic-only training in slowing cognitive and motor decline in patients with dementia. No mediating effects between improvements in cognitive function via improved motor function were found. Future research into the underlying mechanistic associations is needed.
Willem J.R. Bossers; Lucas van der Woude; Froukje Boersma; Tibor Hortobágyi; Erik J.A. Scherder; Marieke J.G. van Heuvelen. A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial. The American Journal of Geriatric Psychiatry 2015, 23, 1106 -1116.
AMA StyleWillem J.R. Bossers, Lucas van der Woude, Froukje Boersma, Tibor Hortobágyi, Erik J.A. Scherder, Marieke J.G. van Heuvelen. A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial. The American Journal of Geriatric Psychiatry. 2015; 23 (11):1106-1116.
Chicago/Turabian StyleWillem J.R. Bossers; Lucas van der Woude; Froukje Boersma; Tibor Hortobágyi; Erik J.A. Scherder; Marieke J.G. van Heuvelen. 2015. "A 9-Week Aerobic and Strength Training Program Improves Cognitive and Motor Function in Patients with Dementia: A Randomized, Controlled Trial." The American Journal of Geriatric Psychiatry 23, no. 11: 1106-1116.
Elderly individuals with dementia are vulnerable for a decline in physical functioning and basic activities of daily living (BADL) which can lead to a decline in autonomy and participation. This study reviews the effect of physical activity on physical functioning and BADL in elderly subjects with dementia. A systematic search of the literature was performed. Key words related to the elderly, dementia, exercise interventions and physical outcome measures were used. Sixteen studies were included. It was found that physical activity was beneficial in all stages of dementia. Multicomponent interventions (e.g. a combination of endurance, strength and balance) led to larger improvements in gait speed, functional mobility and balance, compared to progressive resistance training alone. BADL and endurance improved but were only assessed in multicomponent interventions. Lower-limb strength improved equally in multicomponent interventions and progressive resistance training. Multicomponent interventions can improve physical functioning and BADL in elderly subjects regardless of the stage of dementia. The best results were obtained in the interventions with the largest training volume. However, the small number of high-quality studies, and heterogeneity of the participants and interventions prevent us from drawing firm conclusions. Recommendations are given with respect to methodological issues, further research and practical guidelines.
Christiaan G. Blankevoort; Marieke J. G. Van Heuvelen; Froukje Boersma; Helga Luning; Jeltsje De Jong; Erik J. A. Scherder. Review of Effects of Physical Activity on Strength, Balance, Mobility and ADL Performance in Elderly Subjects with Dementia. Dementia and Geriatric Cognitive Disorders 2010, 30, 392 -402.
AMA StyleChristiaan G. Blankevoort, Marieke J. G. Van Heuvelen, Froukje Boersma, Helga Luning, Jeltsje De Jong, Erik J. A. Scherder. Review of Effects of Physical Activity on Strength, Balance, Mobility and ADL Performance in Elderly Subjects with Dementia. Dementia and Geriatric Cognitive Disorders. 2010; 30 (5):392-402.
Chicago/Turabian StyleChristiaan G. Blankevoort; Marieke J. G. Van Heuvelen; Froukje Boersma; Helga Luning; Jeltsje De Jong; Erik J. A. Scherder. 2010. "Review of Effects of Physical Activity on Strength, Balance, Mobility and ADL Performance in Elderly Subjects with Dementia." Dementia and Geriatric Cognitive Disorders 30, no. 5: 392-402.
Helena J. M. Van Alphen; Karin M. Volkers; Christiaan G. Blankevoort; Erik J. A. Scherder; Tibor Hortobágyi; Marieke J. G. Van Heuvelen. Older Adults with Dementia Are Sedentary for Most of the Day. 2021, 1 .
AMA StyleHelena J. M. Van Alphen, Karin M. Volkers, Christiaan G. Blankevoort, Erik J. A. Scherder, Tibor Hortobágyi, Marieke J. G. Van Heuvelen. Older Adults with Dementia Are Sedentary for Most of the Day. . 2021; ():1.
Chicago/Turabian StyleHelena J. M. Van Alphen; Karin M. Volkers; Christiaan G. Blankevoort; Erik J. A. Scherder; Tibor Hortobágyi; Marieke J. G. Van Heuvelen. 2021. "Older Adults with Dementia Are Sedentary for Most of the Day." , no. : 1.