Gloria Soberón-Chávez

Dr. Gloria Soberón-Chávez

Departamento de Biología Molecular y Biotecnología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México. Ciudad Universitaria, Apdo. Postal 70228, CDMX C. P. 04510, México
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Research Focus & Metrics

Academic Career Length

45Years (1982-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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14 November 2000 in Applied Microbiology and Biotechnology
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RMRaina Maier
Raina Maier
Gloria Soberón-ChávezGloria Soberón-Chávez
Gloria Soberón-Chávez

1 October 2005 in Applied Microbiology and Biotechnology
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Gloria Soberón-ChávezGloria Soberón-Chávez
Gloria Soberón-Chávez
FLFrançois Lépine
François Lépine
Eric DézielEric Déziel
Eric Déziel

1 May 2001 in Molecular Microbiology
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RRRahim Rahim
Rahim Rahim
UOUrs A. Ochsner
Urs A. Ochsner
COClarita Olvera
Clarita Olvera
MGMichael Graninger
Michael Graninger
PMPaul Messner
Paul Messner
Gloria Soberón-ChávezGloria Soberón-Chávez
Gloria Soberón-Chávez

5 November 2020 in Microbial Biotechnology
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Gloria Soberón-ChávezGloria Soberón-Chávez
Gloria Soberón-Chávez
AGAbigail González‐Valdez
Abigail González‐Valdez
MSMartín P. Soto‐Aceves
Martín P. Soto‐Aceves
MCMiguel Cocotl‐Yañez
Miguel Cocotl‐Yañez
Summary: Rhamnolipids are biosurfactants with a wide range of industrial applications that entered into the market a decade ago. They are naturally produced by Pseudomonas aeruginosa and some Burkholderia species. Occasionally, some strains of different bacterial species, like Pseudomonas chlororaphis NRRL B‐30761, which have acquired RL‐producing ability by horizontal gene transfer, have been described. P. aeruginosa , the ubiquitous opportunistic pathogenic bacterium, is the best rhamnolipids producer, but Pseudomonas putida has been used as heterologous host for the production of this biosurfactant with relatively good yields. The molecular genetics of rhamnolipids production by P. aeruginosa has been widely studied not only due to the interest in developing overproducing strains, but because it is coordinately regulated with the expression of different virulence‐related traits by the quorum‐sensing response. Here, we highlight how the research of the molecular mechanisms involved in rhamnolipid production have impacted the development of strains that are suitable for industrial production of this biosurfactant, as well as some perspectives to improve these industrial useful strains.

1 January 2020 in Journal of Medical Microbiology
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SGSelene García-Reyes
Selene García-Reyes
Gloria Soberón-ChávezGloria Soberón-Chávez
Gloria Soberón-Chávez
MCMiguel Cocotl-Yañez
Miguel Cocotl-Yañez
Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors such as lectin A, pyocyanin, elastase and rhamnolipids. These compounds are controlled transcriptionally by three quorum-sensing circuits, two based on the synthesis and detection of N-acyl-homoserine-lactone termed the Las and Rhl system and a third system named the Pseudomonas quinolone signal (PQS) system, which is responsible for generating 2-alkyl-4(1 h)-quinolones (AQs). The transcriptional regulator called PqsR binds to the promoter of pqsABCDE in the presence of PQS or HHQ creating a positive feedback-loop. PqsE, encoded in the operon for AQ synthesis, is a crucial protein for pyocyanin production, activating the Rhl system by a still not fully understood mechanism. In turn, the regulation of the PQS system is modulated by Las and Rhl systems, which act positively and negatively, respectively. This review focuses on the PQS system, from its discovery to its role in Pseudomonas pathogenesis, such as iron depletion and pyocyanin synthesis that involves the PqsE protein – an intriguing player of this system.

15 October 2003 in Journal of Bacteriology
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GMGerardo Medina
Gerardo Medina
KJKaty Juárez
Katy Juárez
BVBrenda Valderrama
Brenda Valderrama
Gloria Soberón-ChávezGloria Soberón-Chávez
Gloria Soberón-Chávez
Pseudomonas aeruginosacontains two transcription regulators (LasR and RhlR) that, when complexed with their specific autoinducers (3-oxo-dodecanoyl-homoserine lactone and butanoyl-homoserine lactone, respectively) activate transcription of different virulence-associated traits. We studied the RhlR-dependent transcriptional regulation of therhlABoperon encoding rhamnosyltransferase 1, an enzyme involved in the synthesis of the surfactant monorhamnolipid, and showed that RhlR binds to a specific sequence in therhlABregulatory region, both in the presence and in the absence of its autoinducer. Our data suggest that in the former case it activates transcription, whereas in the latter it acts as a transcriptional repressor of this promoter. RhlR seems to repress the transcription of other quorum-sensing-regulated genes; thus, RhlR repressor activity might be of importance in the finely regulated expression ofP. aeruginosavirulence-associated traits.