Cold sensations of varying intensities are perceived when human skin is subject to diverse environments. The accurate presentation of temperature changes is important to elicit immersive sensations in applications such as virtual reality. In this article, we developed a method to elicit intensity-adjustable non-contact cold sensations based on the vortex effect. We applied this effect to generate cold air at approximately 0 $^\circ$ C and varied the skin temperature over a wide range. The perception of different temperatures can be elicited by adjusting the volume flow rate of the cold air. Additionally, we introduced a cooling model to relate the changes in skin temperature to various parameters such as the cold air volume flow rate and distance from the cold air outlet to the skin. For validation, we conducted measurement experiments and found that our model can estimate the change in skin temperature with a root mean-square error of 0.16 $^\circ$ C. Furthermore, we evaluated the performance of a prototype in psychophysical cold discrimination experiments based on the discrimination threshold. Thus, cold sensations of varying intensities can be generated by varying the parameters. These cold sensations can be combined with images, sounds, and other stimuli to create an immersive and realistic artificial environment.

Thermal sensation is crucial to enhancing our comprehension of the world and enhancing our ability to interact with it. Therefore, the development of thermal sensation presentation technologies holds significant potential, providing a novel method of interaction. Traditional technologies often leave residual heat in the system or the skin, affecting subsequent presentations. Our study focuses on presenting thermal sensations with low residual heat, especially cold sensations. To mitigate the impact of residual heat in the presentation system, we opted for a non-contact method, and to address the influence of residual heat on the skin, we present thermal sensations without significantly altering skin temperature. Specifically, we integrated two highly responsive and independent heat transfer mechanisms: convection via cold air and radiation via visible light, providing non-contact thermal stimuli. By rapidly alternating between perceptible decreases and imperceptible increases in temperature on the same skin area, we maintained near-constant skin temperature while presenting continuous cold sensations. In our experiments involving 15 participants, we observed that when the cooling rate was $-$ 0.2 to $-$ 0.24 $^\circ$ C/s and the cooling time ratio was 30 to 50%, more than 86.67% of the participants perceived only persistent cold without any warmth.

The secondary structure of the peptaibol trichosporin B-V in methanol was investigated in detail by 600 MHz nuclear magnetic resonance spectroscopy. Its fundamental secondary structure was characterized as a helix by the circular dichroism spectrum. Inter-residual nuclear Overhauser effect patterns, ³J_NH-CaH amide coupling constants, hydrogen–deuterium (H–D) exchange rates of the amide protons, and inspection of molecular models showed that the secondary structure of this peptide consists of two major α-helical structures because of a bent structure around a Pro residue, and that the first three amino acid residues of the N-terminal α-helix are arranged predominantly in a 3₁₀-helical fashion.

Water is an essential substance for humans in their daily lives. There are many opportunities for us to come in contact with water, such as cooking, bathing, and swimming. However, few studies have reproduced the sensation of water touching the skin. This study aims to propose a novel midair haptic device, named FlowHaptics, that reproduces the feeling of the force of flowing water over human fingers using multiple air jets. We first estimated the temporal pressure distribution change of water in two-dimensional space using machine-learning-accelerated fluid simulation. We controlled the airflow based on the pressure distribution change obtained from the fluid simulation to reproduce the feeling of flowing water over the fingers using our proposed device, which can control multiple air jets in real time. We performed a psycho-physical evaluation of different flow velocities and a subjective evaluation of different velocity profiles. We found that FlowHaptics reliably created the illusion of the pressure distribution of flowing water on the fingers where the flow velocity could be distinguished within the range of 8.42% to 13.05%, and our estimated flow velocity profile with the configuration of three air jets felt more similar to flowing water when compared to a constant velocity profile according to the users.

The interaction between amine local anesthetic dibucaine and pig erythrocyte membranes has been studied by 1H-NMR spectroscopy. Two-dimensional NOESY spectra were observed to obtain the conformations of cationic and uncharged forms of dibucaine. The NMR spectra were measured at pH 7.4, and the temperature was raised (318-348 K) to increase the concentration of the uncharged form of dibucaine, taking the temperature dependence of the pKa value of dibucaine into consideration. The dibucaine in a buffered solution showed the presence of two kinds of distinctly different species; one is assignable to the cationic form and the other to the uncharged form of dibucaine, suggesting that the protonation equilibrium between the two forms is slow in the presently employed experimental condition. The uncharged dibucaine showed well-defined NOE cross-peaks in the NOESY spectra of the solution containing no erythrocyte membranes, suggesting that its conformation is relatively fixed. Interestingly, however, it was only the cationic dibucaine that showed NOE cross-peaks when the solution contained the membranes, and experiments were performed at a much shorter mixing time for the buildup of NOEs, suggesting that it appeared only the cationic form of dibucaine is interacting with the membranes. It was concluded that the uncharged form of dibucaine, which was produced by raising the temperature, formed micelles in a buffered solution. Thus formed micelles didn't interact with membranes owing to the repulsive forces between the structured water surrounding the micelles and those at the surface of the membranes. This conclusion could be a promising reason why the cationic local anesthetics are much more active than their uncharged counterparts in blocking nerve conduction.