Pagona Gouletsou

Dr. Pagona Gouletsou

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Research Focus & Metrics

Academic Career Length

25Years (2002-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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2 August 2019 in Science
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Journal Article
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ABAdrian Baez-Ortega
Adrian Baez-Ortega
KGKevin Gori
Kevin Gori
ASAndrea Strakova
Andrea Strakova
JAJanice L. Allen
Janice L. Allen
KAKaren M. Allum
Karen M. Allum
EMElizabeth P. Murchison
Elizabeth P. Murchison
It's a dog's life: Canine transmissible venereal tumor is one of the few cancer lineages that is transferred among individuals through contact. It arose millennia ago and has been evolving independently from its hosts ever since. Baez-Ortega et al. looked at the phylogenetic history of the cancer and describe several distinctive mutational patterns (see the Perspective by Maley and Shibata). Most notably, both positive and negative selection show only weak or distant signals. This suggests that the main driver of the lineage's evolution is neutral genetic drift. Understanding the influence of drift may reshape how we think about long-term cancer evolution. Science , this issue p. eaau9923 ; see also p. 440

25 December 2002 in Theriogenology
Verified
Journal Article
Closed access
PGPagona Gouletsou
Pagona Gouletsou
GAG.S. Amiridis
G.S. Amiridis
PCP.J. Cripps
P.J. Cripps
TLT. Lainas
T. Lainas
KDK. Deligiannis
K. Deligiannis
GFG.C. Fthenakis
G.C. Fthenakis

16 June 2020 in Nature Communications
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Journal Article
Open access
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ASAndrea Strakova
Andrea Strakova
TNThomas Nicholls
Thomas Nicholls
ABAdrian Baez-Ortega
Adrian Baez-Ortega
MLMáire Ní Leathlobhair
Máire Ní Leathlobhair
ASAlexander T. Sampson
Alexander T. Sampson
EMElizabeth P. Murchison
Elizabeth P. Murchison
Autonomous replication and segregation of mitochondrial DNA (mtDNA) creates the potential for evolutionary conflict driven by emergence of haplotypes under positive selection for ‘selfish’ traits, such as replicative advantage. However, few cases of this phenomenon arising within natural populations have been described. Here, we survey the frequency of mtDNA horizontal transfer within the canine transmissible venereal tumour (CTVT), a contagious cancer clone that occasionally acquires mtDNA from its hosts. Remarkably, one canine mtDNA haplotype, A1d1a, has repeatedly and recently colonised CTVT cells, recurrently replacing incumbent CTVT haplotypes. An A1d1a control region polymorphism predicted to influence transcription is fixed in the products of an A1d1a recombination event and occurs somatically on other CTVT mtDNA backgrounds. We present a model whereby ‘selfish’ positive selection acting on a regulatory variant drives repeated fixation of A1d1a within CTVT cells.

1 December 2015 in Veterinary Microbiology
Verified
Journal Article
Closed access
PGPagona Gouletsou
Pagona Gouletsou
GFG.C. Fthenakis
G.C. Fthenakis

31 December 2010 in Theriogenology
Verified
Journal Article
Closed access
PGPagona Gouletsou
Pagona Gouletsou
AGA.D. Galatos
A.D. Galatos
LLL.S. Leontides
L.S. Leontides
ASA.I. Sideri
A.I. Sideri

1 December 2010 in Reproduction in Domestic Animals
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Journal Article
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PGPagona Gouletsou
Pagona Gouletsou
AGAd Galatos
Ad Galatos
LLLs Leontides
Ls Leontides
ASAi Sideri
Ai Sideri