Lie Gao earned his Doctorate of Medicine in Clinical Medicine from the West China Center of Medical Sciences, Sichuan University, Chengdu, in 1984, a Master of Science in Physiology from the Guizhou Medical University, Guiyang, in 1989, and a Doctorate of Philosophy in Physiology from the Peking Union Medical College, Beijing in 2001. He is an Associate Professor in the Department of Anesthesiology at the University of Nebraska Medical Center, Omaha, USA. The long-term goal of his laboratory is to elucidate cardiovascular regulation in physiological, pathological, and pharmacological circumstances, from the whole animal level down to the molecular mechanisms. His current research focuses on the mechanisms underlying exercise-induced cardiovascular benefits based on the antioxidant transcription factor nuclear factor (erythroid-derived 2)-like 2 (Nrf2) in skeletal muscle and the transfer of antioxidant enzymes from contracting muscle to the cardiovascular organs via circulating extracellular vesicles (EVs).