Laura Guillen-Aguinaga

Ms. Laura Guillen-Aguinaga

orcid

Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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LOLuc ONAMBELE
Luc ONAMBELE
WOWilfrido Ortega-Leon
Wilfrido Ortega-Leon
SGSara Guillen-Aguinaga
Sara Guillen-Aguinaga
Maria João ForjazMaria João Forjaz
Maria João Forjaz
AYAmanuel Yoseph
Amanuel Yoseph
Francisco Guillen-GrimaFrancisco Guillen-Grima
Francisco Guillen-Grima
Background: United Nations Sustainable Development Goals state that by 2030, the global maternal mortality rate (MMR) should be lower than 70 per 100,000 live births. MMR is still one of Africa’s leading causes of death among women. The leading causes of maternal mortality in Africa are hemorrhage and eclampsia. This research aims to study regional trends in maternal mortality (MM) in Africa. Methods: We extracted data for maternal mortality rates per 100,000 births from the United Nations Children’s Fund (UNICEF) databank from 2000 to 2017, 2017 being the last date available. Joinpoint regression was used to study the trends and estimate the annual percent change (APC). Results: Maternal mortality has decreased in Africa over the study period by an average APC of −3.0% (95% CI −2.9; −3,2%). All regions showed significant downward trends, with the greatest decreases in the South. Only the North African region is close to the United Nations’ sustainable development goals for Maternal mortality. The remaining Sub-Saharan African regions are still far from achieving the goals. Conclusions: Maternal mortality has decreased in Africa, especially in the South African region. The only region close to the United Nations’ target is the North African region. The remaining Sub-Saharan African regions are still far from achieving the goals. The West African region needs more extraordinary efforts to achieve the goals of the United Nations. Policies should ensure that all pregnant women have antenatal visits and give birth in a health facility staffed by specialized personnel.

20 November 2023 in Clinics and Practice
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Journal Article
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Francisco Guillen-GrimaFrancisco Guillen-Grima
Francisco Guillen-Grima
SGSara Guillen-Aguinaga
Sara Guillen-Aguinaga
LGLaura Guillen-Aguinaga
Laura Guillen-Aguinaga
RBROSA MARÍA ALÁS BRUN
ROSA MARÍA ALÁS BRUN
LOLuc ONAMBELE
Luc ONAMBELE
Ines Aguinaga-Ontoso  BA(Psichology) MD  MPH PhDInes Aguinaga-Ontoso BA(Psichology) MD MPH PhD
Ines Aguinaga-Ontoso BA(Psichology) MD MPH PhD
The rapid progress in artificial intelligence, machine learning, and natural language processing has led to increasingly sophisticated large language models (LLMs) for use in healthcare. This study assesses the performance of two LLMs, the GPT-3.5 and GPT-4 models, in passing the MIR medical examination for access to medical specialist training in Spain. Our objectives included gauging the model’s overall performance, analyzing discrepancies across different medical specialties, discerning between theoretical and practical questions, estimating error proportions, and assessing the hypothetical severity of errors committed by a physician. Material and methods: We studied the 2022 Spanish MIR examination results after excluding those questions requiring image evaluations or having acknowledged errors. The remaining 182 questions were presented to the LLM GPT-4 and GPT-3.5 in Spanish and English. Logistic regression models analyzed the relationships between question length, sequence, and performance. We also analyzed the 23 questions with images, using GPT-4’s new image analysis capability. Results: GPT-4 outperformed GPT-3.5, scoring 86.81% in Spanish (p < 0.001). English translations had a slightly enhanced performance. GPT-4 scored 26.1% of the questions with images in English. The results were worse when the questions were in Spanish, 13.0%, although the differences were not statistically significant (p = 0.250). Among medical specialties, GPT-4 achieved a 100% correct response rate in several areas, and the Pharmacology, Critical Care, and Infectious Diseases specialties showed lower performance. The error analysis revealed that while a 13.2% error rate existed, the gravest categories, such as “error requiring intervention to sustain life” and “error resulting in death”, had a 0% rate. Conclusions: GPT-4 performs robustly on the Spanish MIR examination, with varying capabilities to discriminate knowledge across specialties. While the model’s high success rate is commendable, understanding the error severity is critical, especially when considering AI’s potential role in real-world medical practice and its implications for patient safety.

4 December 2025 in Data
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Journal Article
Open access
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MGMiriam Guillen-Aguinaga
Miriam Guillen-Aguinaga
EAEnrique Aguinaga-Ontoso
Enrique Aguinaga-Ontoso
LGLaura Guillen-Aguinaga
Laura Guillen-Aguinaga
Francisco Guillen-GrimaFrancisco Guillen-Grima
Francisco Guillen-Grima
Ines Aguinaga-Ontoso  BA(Psichology) MD  MPH PhDInes Aguinaga-Ontoso BA(Psichology) MD MPH PhD
Ines Aguinaga-Ontoso BA(Psichology) MD MPH PhD
Data quality is fundamental to scientific integrity, reproducibility, and evidence-based decision-making. Nevertheless, many datasets lack transparency in their collection and curation, undermining trust and reusability across research domains. This narrative review synthesizes scientific and technical literature published between 1996 and 2025, complemented by international standards (ISO/IEC 25012, ISO 8000), to provide an integrated overview of data quality frameworks, governance, and ethical considerations in the era of Artificial Intelligence (AI). Sources were retrieved from PubMed, Scopus, Web of Science, and grey literature. Across sectors, accuracy, completeness, consistency, timeliness, and accessibility consistently emerged as universal quality dimensions. Evidence from healthcare, business, and public administration suggests that poor data quality leads to substantial financial losses, operational inefficiencies, and erosion of trust. Emerging frameworks are increasingly integrating FAIR principles (Findability, Accessibility, Interoperability, Reusability) and incorporating ethical safeguards, including bias mitigation in AI systems. Data quality is not solely a technical issue but a socio-organizational challenge that requires robust governance and continuous assurance throughout the data lifecycle. Embedding quality and ethical governance into data management practices is crucial for producing trustworthy, reusable, and reproducible data that supports sound science and informed decision-making.

29 August 2023 in Epidemiologia
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Journal Article
Open access
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LOLuc ONAMBELE
Luc ONAMBELE
SGSara Guillen-Aguinaga
Sara Guillen-Aguinaga
LGLaura Guillen-Aguinaga
Laura Guillen-Aguinaga
WOWilfrido Ortega-Leon
Wilfrido Ortega-Leon
RMRocio Montejo
Rocio Montejo
Francisco Guillen-GrimaFrancisco Guillen-Grima
Francisco Guillen-Grima
With the United Nations Sustainable Development Goals (SDG) (2015–2030) focused on the reduction in maternal mortality, monitoring and forecasting maternal mortality rates (MMRs) in regions like Africa is crucial for health strategy planning by policymakers, international organizations, and NGOs. We collected maternal mortality rates per 100,000 births from the World Bank database between 1990 and 2015. Joinpoint regression was applied to assess trends, and the autoregressive integrated moving average (ARIMA) model was used on 1990–2015 data to forecast the MMRs for the next 15 years. We also used the Holt method and the machine-learning Prophet Forecasting Model. The study found a decline in MMRs in Africa with an average annual percentage change (APC) of −2.6% (95% CI −2.7; −2.5). North Africa reported the lowest MMR, while East Africa experienced the sharpest decline. The region-specific ARIMA models predict that the maternal mortality rate (MMR) in 2030 will vary across regions, ranging from 161 deaths per 100,000 births in North Africa to 302 deaths per 100,000 births in Central Africa, averaging 182 per 100,000 births for the continent. Despite the observed decreasing trend in maternal mortality rate (MMR), the MMR in Africa remains relatively high. The results indicate that MMR in Africa will continue to decrease by 2030. However, no region of Africa will likely reach the SDG target.

28 May 2023 in Life
Verified
Journal Article
Open access
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Ines Aguinaga-Ontoso  BA(Psichology) MD  MPH PhDInes Aguinaga-Ontoso BA(Psichology) MD MPH PhD
Ines Aguinaga-Ontoso BA(Psichology) MD MPH PhD
SGSara Guillen-Aguinaga
Sara Guillen-Aguinaga
LGLaura Guillen-Aguinaga
Laura Guillen-Aguinaga
RBROSA MARÍA ALÁS BRUN
ROSA MARÍA ALÁS BRUN
Francisco Guillen-GrimaFrancisco Guillen-Grima
Francisco Guillen-Grima
Background: More than 270 million participants and 128,893 professional players play soccer. Although UEFA recommendations for nutrition in elite football exist, implementing these guidelines among professional and semiprofessional soccer players remains suboptimal, emphasizing the need for targeted and individualized nutritional strategies to improve adherence to established recommendations. Methods: We conducted a comprehensive search in PubMed, Scopus, Web of Science, and clinical trial registers. Inclusion criteria focused on professional or semiprofessional soccer players, nutrition or diet interventions, performance improvement outcomes, and randomized clinical trial study types. We assessed quality using the Risk of Bias 2 (RoB 2) tool. We identified 16 eligible articles involving 310 participants. No nutritional interventions during the recovery period effectively improved recovery. However, several performance-based interventions showed positive effects, such as tart cherry supplementation, raw pistachio nut kernels, bicarbonate and mineral ingestion, creatine supplementation, betaine consumption, symbiotic supplements, and a high-carbohydrate diet. These interventions influenced various aspects of soccer performance, including endurance, speed, agility, strength, power, explosiveness, and anaerobic capacity. Conclusions: Specific strategies, such as solutions with bicarbonate and minerals, high carbohydrate diets, and supplements like creatine, betaine, and tart cherry, can enhance the performance of professional soccer players. These targeted nutritional interventions may help optimize performance and provide the competitive edge required in professional soccer. We did not find any dietary interventions that could enhance recovery.

22 April 2025 in Nursing Reports
Verified
Journal Article
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LGLaura Guillen-Aguinaga
Laura Guillen-Aguinaga
EREsperanza Rayón
Esperanza Rayón
SGSara Guillen-Aguinaga
Sara Guillen-Aguinaga
BDBlanca Rodríguez Díaz
Blanca Rodríguez Díaz
RMRocio Montejo
Rocio Montejo
Ines Aguinaga-Ontoso  BA(Psichology) MD  MPH PhDInes Aguinaga-Ontoso BA(Psichology) MD MPH PhD
Ines Aguinaga-Ontoso BA(Psichology) MD MPH PhD
Background: Nursing Schools are incorporating Mixed Reality (MR) into student training to enable them to confront challenging or infrequently encountered scenarios in their practice and ensure their preparedness. This systematic review evaluates the benefits and challenges of implementing MR in nursing curricula. Materials and Methods: A search was conducted in PubMed, WOS, Scopus, Embase, and CINAHL for studies published between 2011 and 2023. The search strategy used was “(nurses OR nurse OR nursing) AND mixed reality AND simulation”. Inclusion criteria required that studies focus on undergraduate nursing students and be written in English or Spanish. Exclusion criteria included reviews, bibliometric studies, and articles that did not separately report undergraduate nursing student results. Quality was evaluated with the JBI Critical Appraisal Checklist for Qualitative Research and the Newcastle-Ottawa Scale. A meta-analysis was conducted on studies with control groups to compare MR’s effectiveness against traditional teaching methods. Results: Thirty-three studies met the inclusion criteria. MR was widely used to improve clinical judgment, patient safety, technical skill acquisition, and student confidence. The meta-analysis found that MR reduced anxiety (Cohen’s d = −0.73, p < 0.001). However, its impact on knowledge acquisition and skill development was inconsistent. There was no improvement over traditional methods (p = 0.466 and p = 0.840). Despite positive qualitative findings, methodological variability, small sample sizes, and publication bias contributed to mixed quantitative results. The main challenges were cybersickness, usability, high costs, and limited institutional access to MR technology. Conclusions: Although MR can help nursing education by decreasing students’ anxiety, its efficacy remains inconclusive. Future research should use larger, randomized controlled trials to validate MR’s role in nursing education.