Architects’ approach towards colour in architectural design evolved radically in the recent 50 years, and ranges from a modernist aversion to a vernacular appreciation. These changes were linked to the development of culture, technology and scientific knowledge in different areas connected to human functioning. The authors have examined evolution in design of tall buildings in the Isle of Dogs in London (UK) since the 1980s. The area experienced major growth spurs in the turn of the 20th and 21st centuries, resulting in the greatest concentration of tall buildings in London today. The Island has been a playground for architects who have developed a range of approaches to the design of towers. The authors observed the evolution of architectural style, analyzed application of colour and made connections between scale, beauty and human behaviour. They concluded that colour in tall buildings’ architecture on the Isle of Dogs is predominantly used to disguise their massing. Colour detail facilitates the domestic feel of a public realm. Therefore, alongside decorative quality, and if considerately applied, colour may positively influence the quality of living and working environments.