Quality of life can be expressed as a highly subjective measure of happiness, which is an important part of many financial and non-financial decisions. The issue of quality of life, namely its quantification, is a current topic, evidenced by a number of literary sources in both foreign and domestic literature. The paper deals with this issue in the conditions of the Slovak Republic and studies the quality of life for each region of Slovakia with respect to the given indicators. In this paper, we deal with the use of the methods of multi-criteria analysis in evaluating the quality of life in Slovakia. The aim of this paper is to highlight that it is important to monitor the level of quality of life at the regional level and that one of the indicators influencing the quality of life in the region may be its location in relation to neighboring countries.