My research career is focused on the development of genome engineering tools broadly applicable to studying and treating human genetic diseases. Delivery of gene editing tools is perhaps one of the key barrier to widespread use of the genome editing technologies. I have been involved in several research projects to engineer viral delivery systems that can be combined with genetic editing nucleases such as CRISPR/Cas9. I received my Ph.D. under the supervision of Dr. Ramirez at the viral vector group (CNIC). During that period, I engineered novel viral systems for gene delivery (AAV, AdV & LV) improving their potential as tools for basic and translational research. Particularly, I developed a system that promotes the target integration of any transgene in a pre-designed genomic region. Most importantly, an optimization of that original system has been granted with a worldwide patent (WO2015078999), and the technology has been licensed to a biotechnology company (VIVEBiotech). During my Ph.D. training I also participated in several collaborative projects including a study developed with the CNIO Molecular Cytogenetics’ lab. In this project, we harness the CRISPR/Cas9 system to efficiently recreate cancer related chromosomal rearrangements in human cellular models. This approach paves the way to interrogate the function of cancer initiation events in a wild type genomic context.