Introduction: Measuring the performance of interprofessional primary care is needed to examine whether this model of care is achieving its desired outcomes on patient care and health system effectiveness as well as to guide quality improvement initiatives. The aim of this scoping review is to map the literature on primary care performance measurement indicators to determine the extent to which current indicators capture or could be adapted to capture processes, outputs and outcomes that reflect interprofessional primary care. Methods and analysis: The review will be guided by the six-stage framework by Arksey and O’Malley (2005). MEDLINE, Embase, CINAHL, grey literature and the reference list of key studies will be searched to identify any study, published in English or French between 2000 and 2022, related to the concepts of performance indicators, frameworks, interprofessional teams and primary care. Two reviewers will independently screen all abstracts and full-text studies for inclusion. Eligible indicators will be classified according to process, output and outcome domains proposed by two validated frameworks. This study started in November 2022 and is expected to be completed by July 2023. Ethics and dissemination: This review does not require ethical approval. The results will be disseminated through a peer-reviewed publication, conference presentations and presentations to stakeholders.

Introduction Obesity, a complex chronic disease, is on the rise, leading to increased mortality, morbidity and societal challenges. This study explores intersectoral interventions focusing on the needs of people living with obesity (PLO). Methods and analysis An environmental scan of the published and unpublished literature will be conducted using Medline, Embase, Cumulated Index in Nursing and Allied Health Literature and specialised websites. To be included, citations must describe or evaluate an intersectoral intervention for PLO developed in primary care or community settings. Title and abstract, full-text screening and extraction will be completed by two independent reviewers. Discrepancies will be resolved through consensus. Data such as study and intervention characteristics will be extracted using a customised extraction template on Covidence and synthesised in a table. Findings from this study will guide intervention design and enhance intersectoral collaboration in primary care and community settings. A multidisciplinary group, including clinicians and two patient partners, will be consulted throughout the process. Despite the challenges of defining intersectoral collaboration and limited data on obesity as a chronic disease, this study is foundational for developing effective intersectoral interventions for PLO. Ethics and dissemination Ethics approval is not required. Findings will be disseminated through presentations at relevant conferences and other knowledge translation activities and will be published in a peer-reviewed journal.

Cyclopeptidic photosensitizer prodrugs (cPPPs) are compounds designed to specifically target overexpressed hydrolases such as serine proteases, resulting in their specific activation in close proximity to tumor cells. In this study, we explored a series of conjugates that can be selectively activated by the urokinase plasminogen activator (uPA). They differ from each other by their pheophorbide a (Pha) loading, their number of PEG chains and the eventual presence of black hole quenchers (BHQ3). The involvement of a peptidic linker between the drugs and the cyclopeptidic carrier allows specific cleavage by uPA. Restoration of the photophysical activity was observed in vitro on A549 lung and MCF7 breast cancer cells that exhibited an increase in red fluorescence emission up to 5.1-fold and 7.8-fold, respectively for uPA-cPPQ_2+2/5. While these cPPP conjugates do not show dark toxicity, they revealed their phototoxic potential in both cell lines at 5 µM of Pha_eq and a blue light fluence of 12.7 J/cm² that resulted in complete cell death with almost all conjugates. This suggests, in addition to the promising use for cancer diagnosis, a use as a PDT agent. Intravenous injection of tetrasubstituted conjugates in fertilized hen eggs bearing a lung cancer nodule (A549) showed that a double PEGylation was favorable for the selective accumulation of the unquenched Pha moieties in the tumor nodules. Indeed, the diPEGylated uPA-cPPP_4/5² induced a 5.2-fold increase in fluorescence, while the monoPEGylated uPA-cPPP_4/5 or uPA-cPPQ_2+2/5 led to a 0.4-fold increase only.

Introduction: Intersectoral collaboration is a collaborative approach between the health sectors and other sectors to address the interdependent nature of the social determinants of health associated with chronic diseases such as diabetes. This scoping review aims to identify intersectoral health interventions implemented in primary care and community settings to improve the well-being and health of people living with type 2 diabetes. Methods and analysis: This protocol is developed by the Arksey and O’Malley (2005) framework for scoping reviews and the Levac et al methodological enhancement. MEDLINE, Embase, CINAHL, grey literature and the reference list of key studies will be searched to identify any study, published between 2000 and 2023, related to the concepts of intersectorality, diabetes and primary/community care. Two reviewers will independently screen all titles/abstracts, full-text studies and grey literature for inclusion and extract data. Eligible interventions will be classified by sector of action proposed by the Social Determinants of Health Map and the conceptual framework for people-centred and integrated health services and further sorted according to the actors involved. This work started in September 2023 and will take approximately 10 months to be completed. Ethics and dissemination: This review does not require ethical approval. The results will be disseminated through a peer-reviewed publication and presentations to stakeholders.