A growing body of evidence shows that reducing the duration of untreated illness (DUI) correlates with improved clinical outcome and course of depression. However, the factors involved in delaying treatment contact after the first onset of lifetime depression are not fully understood. This cross-sectional study aims to identify the characteristics that may predict the delay in initial treatment contact after the first onset of lifetime depression by comparing the socio-demographics and clinical characteristics between those with longer and shorter DUI in a well-characterized Japanese clinical sample. Ninety-five patients with depression with longer (>12 months) and shorter DUI (≤12 months) at three Japanese outpatient clinics were studied. Subjects received a comprehensive evaluation, including semi-structured clinical interviews and assessment battery, and their clinical charts were reviewed. Of the total sample, the median of DUI was 4 months (interquartile range (IQR) 25th–75th percentile, 2–13). We found that 72.6% of patients seek treatment contact within the first year of depression onset. Multivariate logistic regression analysis showed that longer DUI in patients was associated with marital status (never married). Further, the DSM-IV melancholic features approached significance. Our findings suggest that most Japanese patients with depression are likely to seek treatment within 1 year of onset, and that marital status and melancholia may be potential predictors of the delay in the initial treatment contact after the first onset of lifetime depression.

(1) Background: The efficacy of the Unified Protocol (UP), a transdiagnostic cognitive-behavioral therapy, with trauma-focused exposure has not been sufficiently demonstrated for post-traumatic stress disorder (PTSD) with multiple comorbidities. This study examined the effects of UP treatment with trauma-focused exposure on symptoms of PTSD and comorbidities in a client who was hesitant about exposure. (2) Methods: The client, who had comorbid dysthymia, social anxiety disorder, agoraphobia, and bulimia nervosa, participated in the UP for 20 sessions over 6 months. The principal diagnosis and symptoms of the comorbid disorders were assessed at baseline, post-intervention, and at the 3-month follow-up. This treatment was conducted as part of a clinical study (UMIN000008322). (3) Results: The client showed improvement in the principal diagnosis and symptoms of the comorbid disorders post-intervention compared with baseline and no longer met the diagnostic criteria for any of the disorders. Considerable symptom improvement was observed with imaginal exposure to trauma memories. (4) Conclusions: The UP was an effective alternative treatment for PTSD and symptoms of comorbidities in this client who was hesitant about exposure to traumatic memories, and that the inclusion of trauma-focused exposure provided sufficient therapeutic effects. Further research is needed to examine the generalizability of our findings.

The group format of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders (UP) shows promise as a efficient method for delivering established and effective psychological treatments for emotional disorders. The implementation of psychological treatment in a group format varies according to a country’s local circumstances, policies, and culture. To date, there are no comprehensive reviews of aspects related to settings, participants, providers, and interventions for applying the UP in a group context. Therefore, we have prepared a scoping review protocol to clarify the fields, participant characteristics, intervention structures, and therapist training methods related to group-format UP, aiming to facilitate its implementation across diverse regions and contexts. Based on this protocol, the scoping review will follow the Joanna Institute guidelines and PRISMA statement extensions for scoping reviews. The review will include studies of the group format of UP that describe symptoms of emotional disorders in adults. The following databases will be searched: PubMed, MEDLINE, Web of Science, PsycINFO, and ClinicalTrials.gov. The selected data will be organized according to four predefined research questions. This scoping review will provide suggestions to promote the application and implementation of the UP in a group format and contribute to disseminating evidence-based psychological treatment.