The intermittent energy supply from distributed resources and the coupling of different energy and application sectors play an important role for future energy systems. Novel operational concepts require the use of widespread and reliable Information and Communication Technology (ICT). This paper presents the approach of a research project that focuses on the development of an innovative operational concept for a Smart Integrated Energy System (SIES), which consists of a physical architecture, ICT and energy management strategies. The cellular approach provides the architecture of the physical system in combination with Transactive Control (TC) as the system’s energy management framework. Independent dynamic models for each component, the physical and digital system, operational management and market are suggested and combined in a newly introduced co-simulation platform to create a holistic model of the integrated energy system. To verify the effectiveness of the operational concept, energy system scenarios are derived and evaluation criteria are suggested which can be employed to evaluate the future system operations.