Background/Objectives: This study presents a novel and comprehensive investigation into the anti-colorectal cancer (CRC) effects and underlying mechanisms of Eruca sativa (E. sativa) using an integrated approach combining network pharmacology, molecular docking and molecular dynamics simulation. Methods: Using an integrated approach, six bioactive compounds and 40 potential targets were identified. A compound–target network was constructed, and enrichment analysis was performed to explore the key pathways influenced by E. sativa. Molecular docking analysis was used to evaluate the binding interactions between the identified compounds and key CRC-related targets (AKT1, PGR, MMP9, and PTGS2). Furthermore, molecular dynamics simulation was utilized to confirm the stability and reliability of these interactions. Results: The study found that E. sativa exhibits strong anticancer potential, particularly through major compounds such as β-ionone, 1-octanol, isorhamnetin, 2-hexenal, propionic acid, and quercetin. Molecular docking revealed favorable binding interactions between these compounds and key CRC targets, with quercetin and isorhamnetin showing the highest binding affinities. Additionally, molecular dynamics simulations validated the stability of these interactions, reinforcing their therapeutic relevance. Conclusions: This study provides valuable insights into the pharmacological mechanisms of E. sativa against CRC, highlighting its potential as a natural anticancer agent. These findings pave the way for future clinical studies to validate the efficacy and safety of E. sativa and its bioactive compounds, potentially contributing to the development of novel, plant-based therapeutic strategies for CRC treatment.

Background The most common cause of dizziness in elderly is benign paroxysomal positional vertigo(BPPV) Accounting for 26% of all dizziness, The incidence of dizziness of BPPV increases with each decade. Benign paroxysomal positional vertigo (BPPV), is a common vertigo disorder in which otoconia, Normally adherent to the utricle become displaced into semicircular canals (Lanska and Remler, 1997) It can be clear from the semicircular canals by canalith repositioning resolving the dizziness (white et al), ideally whatever the maneuver is applied several times in the course of the treatment sessions, it is possible to have recurrence which approach 50% over 1–2 years (Beyan et al, 2000) Objective The objective of the study is to find the addition of visual and proprioceptive exercises will show the variation in dizziness caused by BPPV. Method 20 subjects were divided into 2 groups Group A control group was received the Brandt daroff exercises Group B experimental group was received the Brandt daroff exercises +visual and proprioceptive exercises After that patient received design treatment protocol for seven days. And after that all subject has to outcome measure with dizziness handicap inventory 20 subjects were taken both males and females it mean age group A and group B is 48.2 and 46.5 And pre and post treatment scores were measured by using DHI and Berg balance scale. The total duration of study was 9 weeks, 5 session per week Results The mean and standard deviation of DHI and Berg balance scale for group A and Group B was measured. According to independent Sample T-test DHI and Berg balance scale score T-value is 1.214 and 1.422 The results show Group B p-value was significant at 95% confidence interval Conclusion The study concluded that adding the visual and proprioceptive exercises along with the brandt daroff exercises is effective in reducing the dizziness and improving the balance

This study aims to investigate the potential anticancer effects of erucin, an isothiocyanate derived from Eruca sativa, in triple-negative breast cancer (TNBC) by predicting molecular targets and evaluating its in vitro effects on TNBC cell proliferation, apoptosis and cell cycle distribution. Potential protein targets of erucin were identified using SwissTargetPrediction, resulting in 117 targets, of which 84 overlapped with TNBC-related genes sourced from GeneCards, DisGeNET, and OMIM. Protein–protein interaction analysis was performed to identify key hub genes. In vitro experiments were conducted using MDA-MB-231 TNBC cells to assess dose-dependent effects on cell viability. Flow cytometry was employed to evaluate apoptotic cell populations and cell cycle distribution. Protein–protein interaction analysis identified ten hub genes, including AKT1, STAT3, EGFR, and MMP9, representing highly connected nodes within the predicted interaction network. In vitro studies showed dose-dependent reduction in MDA-MB-231 cell viability following erucin treatment, with an IC₅₀ of approximately 48.87 µg/mL. Flow cytometry revealed increased apoptotic cell population and G1 phase accumulation. These findings suggest that erucin is associated with cytotoxic and antiproliferative effects in TNBC cells and may interact with multiple cancer-related targets. However, the identified molecular targets and pathways are based on computational predictions and require further experimental validation. Overall, this study provides a preliminary integrated framework linking computational predictions with experimental observations, which may support future mechanistic and preclinical investigations of erucin in TNBC.