This study aimed to isolate polyprenylated benzophenones from the rootbark of Garcinia celebica and assess their activities in vitro and in silico. The antioxidant activity was evaluated by the DPPH, ABTS, and FRAP methods. The cytotoxicity was evaluated against HeLa, MCF-7, A549, and B16 cancer cell lines. The antiplasmodial activity was performed against the chloroquine-sensitive Plasmodium falciparum strain 3D7. Molecular docking was analyzed on alpha-estrogen receptor (3ERT) and P. falciparum lactate dehydrogenase enzyme (1CET). The prediction of ADMET for the compounds was also studied. For the first time, (-)-cycloxanthochymol, isoxanthochymol, and xanthochymol were isolated from the root bark of Garcinia celebica. The antioxidant and cytotoxicity evaluation showed that all benzophenones exhibited antioxidant activity compared to gallic acid and quercetin as positive controls and also exhibited strong activity against HeLa, MCF-7, A549, and B16 cell lines compared to cisplatin as the positive control. The antiplasmodial evaluation showed that isoxanthochymol exhibited activity against the chloroquine-sensitive P. falciparum strain 3D7. In addition, the in silico molecular docking study supported in vitro activities. The ADMET analysis also indicated the isolated benzophenones are potential oral drug candidates.

Climate is an important element for human life, one of them is to agriculture sector. Global climate change leads to increased frequency and extreme climatic intensity such as storms, floods, and droughts. Rainfall is climate factor that causes the failure of harvest in Merauke. Therefore, rainfall forecast information is very useful in anticipating the occurrence of extreme events that can lead to crop failure. The purpose of this research is to model rainfall using autoregressive integrated moving average (ARIMA) model. The ARIMA model can be used to predict future events using a set of past data, including predicting rainfall. This research was conducted by collecting secondary data from Agency of Meteorology, Climatology, and Geophysics (BMKG) from 2005 until 2017, then the data was analyzed using R.3.4.2. software. The analysis result showed that ARIMA model (2.0,2) as the right model to predict rainfall in Merauke. The result of forecasting based on ARIMA model (2.0,2) for one period ahead is 179 mm of average rainfall, 46 mm of minimum rainfall, and 295 mm of maximum rainfall. Thus it can be concluded that the intensity of rainfall in Merauke has decreased and there was a seasonal shift from the previous period.

Penelitian ini bertujuan untuk mengetahui validitas bahan ajar berbasis komik pada materi hidrokarbon. Jenis penelitian ini adalah penelitian R&D dengan menggunakan model ADDIE. Subjek penelitian ini adalah peserta didik kelas XI IPA SMA Negeri 1 Tanah Miring. Instrumen yang digunakan dalam pengumpulan data adalah angket. Hasil penelitian menunjukkan bahwa pengembangan modul berbasis komik pada materi senyawa hidrokarbon dinyatakan valid dan praktis ditinjau dari aspek validitas, hasil validasi materi sebesar 100% dengan kategori sangat valid, validasi media sebesar 92% dengan kategori sangat valid dan angket peserta didik sebesar 86% dengan kategori sangat valid. Berdasarkan hasil penelitian, modul ajar berbasis komik sebagai bahan ajar materi senyawa hidrokarbon dinyatakan valid untuk digunakan sebagai bahan ajar materi senyawa hidrokarbon.

The Merauke Regency Government has officially issued Regional Regulation Number 6 of 2008 concerning Environmental Conservation, which regulates sand mining of C-class quary. As for all this time the community has been carrying out C-class sand mining activities continuously and without permission. This action resulted in coastal abrasion and had the effect of threatening the existence of Marind people who inhabited the coastal areas of Merauke. This research aimed to explain the role of Indigenous Peoples Institutions in an effort to reduce the actions of sand mining in question. This is very necessary because the customs of the coastal community have an attachment to the Marind Indigenous Peoples Institution which is the holder of customary rights to ulayat land in Merauke regency.The research method used in this research was descriptive qualitative with data collection techniques are observation and interview, while data analysis used data reduction, data presentation, verification, and conclusions. The results of this research indicate that strengthening the role of the Marind Indigenous Peoples Institution is to advocate and provide assistance to the community and intervene through the Sasi tradition which is expected to influence changes in attitudes of the community to be more aware of excessive sand mining.