Global change, population growth, and urbanization have been exerting a severe influence on the environment, including the social system and ecosystem. To find solutions based on nature, clarifying the complicated mechanisms and feedback among land use/land cover changes, ecosystem services, and human well-being, is increasingly crucial. However, the in-depth linkages among these three elements have not been clearly and systematically illustrated, present research paths have not been summarized well, and the future research trends on this topic have not been reasonably discussed. In this sense, the purpose of this paper is to provide an insight into how land use/land cover changes, ecosystem services, and human well-being are linked, as well as their relationships, interacting ways, applications in solving ecological and socioeconomic problems, and to reveal their future research trends. Here, we use a systematic literature review of the peer-reviewed literature to conclude the state of the art and the progress, emphasize the hotspot, and reveal the future trend of the nexus among the three aspects. Results show that (1) ecosystem services are generally altered by the changes in land use type, spatial pattern, and intensity; (2) the nexus among land use change, ecosystem services, and human well-being is usually used for supporting poverty alleviation, ecosystem health, biodiversity conservation, and sustainable development; (3) future research on land use/land cover changes, ecosystem services, and human well-being should mainly focus on strengthening multiscale correlation, driving force analysis, the correlation among different group characteristics, land use types and ecosystem service preferences, and the impact of climate change on ecosystem services and human well-being. This study provides an enhanced understanding of the nexus among the three aspects and a reference for future studies to mitigate the relevant problems.