Commercialization in the meat-processing industry has emerged as one of the major agrobusiness challenges due to the large volume of wastewater produced during slaughtering and cleaning of slaughtering facilities. Slaughterhouse wastewater (SWW) contains proteins, fats, high organic contents, microbes, and other emerging pollutants (pharmaceutical and veterinary residues). It is important to first characterize the wastewater so that adequate treatment techniques can be employed so that discharge of this wastewater does not negatively impact the environment. Conventional characterization bulk parameters of slaughterhouse wastewater include pH, color, turbidity, biochemical oxygen demand (BOD), chemical oxygen demand (COD), total organic carbon (TOC), total suspended solids (TSS), total nitrogen (TN), total phosphorus (TP), and coliform counts. Characterization studies conducted have revealed the effects of the pollutants on microbial activity of SWW through identification of toxicity of antibiotic-resistant strains of bacteria. Due to the high-strength characteristics and complex recalcitrant pollutants, treatment techniques through combined processes such as anaerobic digestion coupled with advanced oxidation process were found to be more effective than stand-alone methods. Hence, there is need to explore and evaluate innovative treatments and techniques to provide a comprehensive summary of processes that can reduce the toxicity of slaughterhouse wastewater to the environment. This work presents a review of recent studies on the characterization of SWW, innovative treatments and technologies, and critical assessment for future research.

Background: Flavones are one of the main subclasses of flavonoids with diverse pharmacological properties. They have been reported to possess antimalarial, antimicrobial, anti-tuberculosis, anti-allergic, antioxidant, anti-inflammatory activities, among others.Objective: The present review summarizes the recent information on the pharmacological properties of naturally occurring and synthetic flavones.Method: Scientific publications referring to natural and synthetic flavones in relation to their biological activities were hand-searched in databases such as SciFinder, PubMed (National Library of Medicine), Science Direct, Wiley, ACS, SciELO, Springer, among others.Results: As per the literature, seventy-five natural flavones were predicted as active compounds with reference to their IC50 (<20 µg/mL) in in vitro studies. Also, synthetic flavones were found active against several diseases.Conclusion: As per the literature, flavones are important sources for the potential treatment of multifactorial diseases. However, efforts toward the development of flavone-based therapeutic agents are still needed. The appearance of new catalysts and chemical transformations is expected to provide avenues for the synthesis of unexplored flavones, leading to the discovery of flavones with new properties and biological activities.