Prof. Peter Babinec

Comenius University in Bratislava, Faculty of Mathematics, Physics and Informatics, Slovakia

Prof. Peter Babinec

Comenius University in Bratislava, Faculty of Mathematics, Physics and Informatics, Slovakia

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Academic Career Length

34Years (1993-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 January 2002 in Bioelectrochemistry

Journal Article

AC-magnetic field controlled drug release from magnetoliposomes: design of a method for site-specific chemotherapy

MB

Melania Babincova

PČ

P Čičmanec

VA

V Altanerová

CA

Cestmir Altaner

PB

1 January 2001 in Journal of Magnetism and Magnetic Materials

Journal Article

Superparamagnetic gel as a novel material for electromagnetically induced hyperthermia

MB

Melania Babincova

DL

Danuta Leszczynska

PS

Paul Sourivong

PČ

Pavol Čičmanec

PB

1 October 2017 in International Journal of Nanomedicine

Journal Article

Human mesenchymal stem cell-derived iron oxide exosomes allow targeted ablation of tumor cells via magnetic hyperthermia

UA

Ursula Altanerova

MB

Melania Babincova

PB

KB

Katarina Benejova

JJ

Jana Jakubechova

CA

Cestmir Altaner

+3

Magnetic hyperthermia, or the heating of tissues using magnetic materials, is a promising approach for treating cancer. We found that human mesenchymal stem cells (MSCs) isolated from various tissues and MSCs expressing the yeast cytosine deaminase::uracil phosphoribosyl transferase suicide fusion gene (yCD::UPRT) can be labeled with Venofer, an iron oxide carbohydrate nanoparticle. Venofer labeling did not affect cell proliferation or the ability to home to tumors. All Venofer-labeled MSCs released exosomes that contained iron oxide. Furthermore, these exosomes were efficiently endocytosed by tumor cells. Exosomes from Venofer-labeled MSCs expressing the yCD::UPRT gene in the presence of the prodrug 5-fluorocytosine inhibited tumor growth in a dose-dependent fashion. The treated tumor cells were also effectively ablated following induction of hyperthermia using an external alternating magnetic field. Cumulatively, we found that magnetic nanoparticles packaged into MSC exosomes are efficiently endocytosed by tumor cells, facilitating targeted tumor cell ablation via magnetically induced hyperthermia.

14 July 2004 in Medical Physics

Journal Article

In vivoheating of magnetic nanoparticles in alternating magnetic field

MB

Melania Babincova

VA

V. Altanerová

CA

Cestmir Altaner

PČ

P. Čičmanec

PB

1 December 2009 in Biomedical Papers

Journal Article

MAGNETIC DRUG DELIVERY AND TARGETING: PRINCIPLES AND APPLICATIONS

MB

Melania Babincova

PB

Background: Nanomaterials are at the leading edge of the rapidly developing field of nanotechnology. Magnetic nanoparticles for cancer therapy and diagnosis have been developed on the basis of their unique physico-chemical properties not prese...

1 April 2000 in Zeitschrift für Naturforschung C

Journal Article

Site-Specific in vivo Targeting of Magnetoliposomes Using Externally Applied Magnetic Field

MB

Melania Babincova

VA

Veronika Altanerová

ML

Miloš Lampert

CA

Cestmir Altaner

EM

Eva Machová

PB

+1

Human serum albumin labeled with technetium-99m was encapsulated together with magnetite particles into phosphatidylcholine/cholesterol liposomes. In order to investigate the stability of this complex and its ability to be used for magnetic drug targeting, the in-vivo distribution after intravenous administration in rats was estimated. For in-vivo targeting an SmCo permanent magnet with intensity ~ 0.3 5 T was attached near the right kidney. Difference between the relative radioactivity in the magnetically targeted right kidney (25.92±5.84%) and non-targeted left kidney (0.93±0.05%) is sufficiently high for relevant clinical applications.

About Me

Professional CV Prof. RNDr. Peter Babinec, CSc. NAME AND SURNAME: Peter Babinec TITLE: Prof., RNDr., CSc. DATE OF BIRTH: 21 February 1962 PLACE OF BIRTH: Hlohovec Slovak nationality PERMANENT RESIDENCE ADDRESS: Mozartova 15 811 02 Bratislava, SR CONTACT ADDRESS: Faculty of Mathematics, Physics and Informatics Comenius University Mlynská dolina F1 842 48 Bratislava, SR Email: babinec@fmph.uniba.sk Telephone: 60295674, 0904180025 FAMILY STATUS: Married EDUCATION: 2008 Inauguration, Technical University of Liberec. 2000 Habilitation, Faculty of Mathematics, Physics and Informatics, Charles University, Bratislava; topic of habilitation thesis: Theoretical study of the structure of molecules. 1990-1995 Postgraduate studies, Faculty of Mathematics, Physics and Informatics, Charles University, Bratislava; thesis topic: Evolution of biomolecular chirality, supervisor prof. Dr. Ing. Ivan Hubac, DrSc. 1981-1986 University studies, Faculty of Mathematics, Physics and Informatics, Charles University, Bratislava; thesis topic: Statistical mechanics of globular proteins, supervisor prof. RNDr. Dusan Chorvat, DrSc. 1977-1981 Secondary school studies, Secondary Industrial School of Electrical Engineering, Piešťany, field of study Computer Technology. 1968-1977 Elementary school, Levice https://sluzby.fmph.uniba.sk/ludia/babinec1

Professional CV Prof. RNDr. Peter Babinec, CSc. NAME AND SURNAME: Peter Babinec TITLE: Prof., RNDr., CSc. DATE OF BIRTH: 21 February 1962 PLACE OF BIRTH: Hlohovec Slovak nationality PERMANENT RESIDENCE ADDRESS: Mozartova 15 811 02 Bratislava, SR CONTACT ADDRESS: Faculty of Mathematics, Physics and Informatics Comenius University Mlynská dolina F1 842 48 Bratislava, SR Email: babinec@fmph.uniba.sk Telephone: 60295674, 0904180025 FAMILY STATUS: Married EDUCATION: 2008 Inauguration, Technical University of Liberec. 2000 Habilitation, Faculty of Mathematics, Physics and Informatics, Charles University, Bratislava; topic of habilitation thesis: Theoretical study of the structure of molecules. 1990-1995 Postgraduate studies, Faculty of Mathematics, Physics and Informatics, Charles University, Bratislava; thesis topic: Evolution of biomolecular chirality, supervisor prof. Dr. Ing. Ivan Hubac, DrSc. 1981-1986 University studies, Faculty of Mathematics, Physics and Informatics, Charles University, Bratislava; thesis topic: Statistical mechanics of globular proteins, supervisor prof. RNDr. Dusan Chorvat, DrSc. 1977-1981 Secondary school studies, Secondary Industrial School of Electrical Engineering, Piešťany, field of study Computer Technology. 1968-1977 Elementary school, Levice https://sluzby.fmph.uniba.sk/ludia/babinec1