Metal-organic frameworks (MOFs) are a novel class of crystalline porous materials, consisting of metal ions and organic linkers. These hybrid materials possess exceptional porosity and specific surface area, which have recently garnered significant interest due to their potential applications in gas separation and storage, energy storage, biomedical imaging, and drug delivery. As MOFs are being explored for biomedical applications, it is essential to comprehensively assess their toxicity. Although nearly ninety thousand MOFs have been investigated, evaluating and optimizing their physico-chemical properties in relevant biological systems remain critical for their clinical translation. In this review article, we first provide a brief classification of MOFs based on their chemical structures. We then conduct a comprehensive evaluation of in vitro and in vivo studies that assess the biocompatibility of MOFs. Additionally, we discuss various approaches to mitigate the critical factors associated with MOF toxicity. To this end, the effects of chemistry, particle size, morphology, and particle aggregation are examined. To better understand MOFs' potential toxicity to living organisms, we also delve into the toxicity mechanisms of nanoparticles (NPs). Furthermore, we introduce and evaluate strategies such as surface modification to reduce the inherent toxicity of MOFs. Finally, we discuss current challenges, the path to clinical trials, and new research directions.

This review outlines sustainable elastomers and green ingredients (derived from renewable resources) used in their formulation are summarized, analyzed, and discussed.

In this work, GTR/thermoplastics blends (in ratio 50/50 and 75/25 wt.%) were prepared by melt-compounding in an internal mixer. During research, trans-polyoctenamer rubber (TOR), ethylene-vinyl acetate copolymer (EVA), ethylene-octene copolymer (EOC), and linear low-density polyethylene (LLDPE), were used in their thermoplastic phase. Microstructure and processing-performance property interrelationships of the studied materials were investigated by: atomic force microscopy (AFM), scanning electron microscopy (SEM), rubber process analyzer (RPA), Mooney viscometer, plastometer, gas chromatography with mass spectrometry, differential scanning calorimetry (DSC), tensile tests and swelling behavior. In blends of thermoplastics with a high content of GTR (50 and 75 wt.%), the thermoplastic modifier type had a significant impact on the processing behavior and microstructure of blends. In terms of the physico-mechanical properties, the GTR/thermoplastics ratio affected elongation at break, hardness, and density, while its effect on tensile strength was negligible. DSC analysis showed that thermoplastics, as modifiers of GTR, should be considered as binders and not plasticizers, as reflected in the almost constant glass-transition temperature of the blends. RPA measurements indicated higher values of G* and η* for GTR-rich blends. SEM showed a rubber-like interfacial break, while AFM confirmed interfacial contact between GTR and thermoplastics.

In this paper, ground tire rubber was modified with dicumyl peroxide and a variable content (in the range of 0–15 phr) of ethylene-vinyl acetate copolymers characterized by different vinyl acetate contents (in the range of 18–39 wt.%). Modification of ground tire rubber was performed via an auto-thermal extrusion process in which heat was generated during internal shearing of the material inside the extruder barrel. The processing, performance properties, and storage stability of modified reclaimed ground tire rubber were evaluated based on specific mechanical energy, infrared camera images, an oscillating disc rheometer, tensile tests, equilibrium swelling, gas chromatography combined with a flame ionization detector, and gas chromatography with mass spectrometry. It was found that the developed formulas of modified GTR allowed the preparation of materials characterized by tensile strengths in the range of 2.6–9.3 MPa and elongation at break in the range of 78–225%. Moreover, the prepared materials showed good storage stability for at least three months and satisfied processability with commercial rubbers (natural rubber, styrene-butadiene rubber).

In this paper, low-temperature extrusion of ground tire rubber was performed as a pro-ecological waste tires recycling method. During this process, ground tire rubber was modified with constant content of dicumyl peroxide and a variable amount of elastomer (in the range: 2.5–15 phr). During the studies, three types of elastomers were used: styrene-butadiene rubber, styrene-ethylene/butylene-styrene grafted with maleic anhydride and ethylene-octene copolymer. Energy consumption measurements, curing characteristics, physico-mechanical properties and volatile organic compounds emitted from modified reclaimed GTR were determined. The VOCs emission profile was investigated using a passive sampling technique, miniature emission chambers system and static headspace analysis and subsequently quantitative or qualitative analysis by gas chromatography. The VOCs analysis showed that in the studied conditions the most emitted volatile compounds are dicumyl peroxide decomposition by-products, such as: α-methylstyrene, acetophenone, α-cumyl alcohol, methyl cumyl ether, while the detection level of benzothiazole (devulcanization “marker”) was very low. Moreover, it was found that the mechanical properties of the obtained materials significantly improved with a higher content of styrene-butadiene rubber and styrene-ethylene/butylene-styrene grafted with maleic anhydride while the opposite trend was observed for ethylene-octene copolymer content.