The combination of microfluidic technology and surface-enhanced Raman spectroscopy (SERS) has the advantages of being label-free, fingerprint spectroscopy, and high sensitivity, which giving the combination great potential for rapid trace-level biological and environmental analysis. In this review, we summarized the recent progress in these two fields, e.g., microfluidics and SERS, including the basic strategies of a simple and versatile microfluidic-SERS detection system and its wide-ranging applications. Moreover, we listed the main challenges and future directions of the microfluidic-SERS systems; proposed on-chip applications beyond SERS; developed a more efficient, more sensitive, and more convenient microfluidic-SERS system; and formed a more complete on-site real-time detection technology.
1 January 2018 in Aerosol and Air Quality Research
The international journal of Aerosol and Air Quality Research (AAQR) covers all aspects of aerosol science and technology, atmospheric science and air quality related issues.
The demand for highly controllable droplet generation methods is very urgent in the medical, materials, and food industries. The droplet generation in a flow-focusing microfluidic device with external mechanical vibration, as a controllable droplet generation method, is experimentally studied. The effects of vibration frequency and acceleration amplitude on the droplet generation are characterized. The linear correlation between the droplet generation frequency and the external vibration frequency and the critical vibration amplitude corresponding to the imposing vibration frequency are observed. The droplet generation frequency with external mechanical vibration is affected by the natural generation frequency, vibration frequency, and vibration amplitude. The droplet generation frequency in a certain microfluidic device with external vibration is able to vary from the natural generation frequency to the imposed vibration frequency at different vibration conditions. The evolution of dispersed phase thread with vibration is remarkably different with the process without vibration. Distinct stages of expansion, shrinkage, and collapse are observed in the droplet formation with vibration, and the occurrence number of expansion–shrinkage process is relevant with the linear correlation coefficient.
Tip clearance cavitation (TCC) is a type of vortex cavitation. It widely exists in axial flow hydraulic machinery and has significant negative influence on the mechanical service life and the operating stability. It is necessary to suppress the tip clearance vortices (TCV) to control the TCC in engineering applications. Based on the analysis of the advantages and disadvantages of the present various suppression strategies, a new coupling method is proposed in this study by combining the damping approach and the diversion approach. Porous medium material is used to realize the coupling effect. A 2 mm span length porous tip is installed on the solid tip surface of a hydrofoil under two gap sizes conditions (representing two types of gap flow pattern), and excellent suppression results of the TCV and TCC are obtained. The characteristics and mechanism of the clearance flow are analyzed by numerical simulation. The numerical accuracy is verified by experimental qualitative observations. The simulation results show that the temporal and spatial stability of the clearance flow field is enhanced, and the leakage velocity and the TCV strength are weakened via the combined action of damping and diversion effects. There is a difference in the damping mechanism between the two gap flow patterns. It is a comprehensive result of viscous dissipation and momentum loss in the jet pattern represented by the small gap size, and primarily, the result of momentum loss in the rolling pattern represented by the large gap size.
Bubble collapse near the liquid-liquid interface was experimentally studied in this paper, and the dynamic evolution of a laser-induced bubble (generation, expansion, and collapse) and the liquid-liquid interface (dent and rebound) were captured by a high-speed shadowgraph system. The effect of the dimensionless distance between the bubble and the interface on the direction of the liquid jet, the direction of bubble migration, and the dynamics of bubble collapse were discussed. The results show that: (1) The jet generated during bubble collapse always directs toward the denser fluid; (2) bubble collapses penetrate the interface when the bubble is close to the interface; (3) three different shapes of the liquid-liquid interface—that is, a mushroom-shaped liquid column, a spike droplet, and a spherical liquid droplet—were observed.