Governance faces complex challenges such as rapid urbanization, increasing socioeconomic inequality, the effects of climate change, and the need for sustainable economic development. These challenges require the active participation of local and regional stakeholders and marginalized groups often excluded from decision-making processes. To improve social inclusion in territorial governance, adopting more participatory and transparent approaches is vital, ensuring that all voices are heard in planning and implementation at the local and regional levels (Kapucu et al., 2024).Public governance is the process by which social actors establish common objectives and coordinate actions to achieve them. This approach stresses that the action of governing is more relevant than the government itself, emphasizing the importance of involving multiple actors in decision-making (Eckersley et al., 2024). Inclusive governance is presented as a key model for meeting the needs of diverse communities, characterized by its ability to integrate governments, civil organizations, and local communities in decisions that affect their lives.The shift towards new governance is due to social diversity, complexity, and dynamism. These elements require public action that resorts to new modes of governance, such as self-government and co-governance. In this context, fostering an open public administration that allows for effective and equitable participation is essential, thus guaranteeing representative and effective public policies and authentic and lasting social justice (Campomori & Casula, 2022). This paper aims to provide an opinion regarding the analysis of how inclusive governance can transform social and political dynamics in diverse communities, highlighting its role in empowering marginalized groups and promoting social justice.

Glycosylation is a post-translational modification that affects the stability, structure, antigenicity and charge of proteins. In the immune system, glycosylation is involved in the regulation of ligand–receptor interactions, such as in B-cell and T-cell activating receptors. Alterations in glycosylation have been described in several autoimmune diseases, such as systemic lupus erythematosus (SLE), in which alterations have been found mainly in the glycosylation of B lymphocytes, T lymphocytes and immunoglobulins. In immunoglobulin G of lupus patients, a decrease in galactosylation, sialylation, and nucleotide fucose, as well as an increase in the N-acetylglucosamine bisector, are observed. These changes in glycoisolation affect the interactions of immunoglobulins with Fc receptors and are associated with pericarditis, proteinuria, nephritis, and the presence of antinuclear antibodies. In T cells, alterations have been described in the glycosylation of receptors involved in activation, such as the T cell receptor; these changes affect the affinity with their ligands and modulate the binding to endogenous lectins such as galectins. In T cells from lupus patients, a decrease in galectin 1 binding is observed, which could favor activation and reduce apoptosis. Furthermore, these alterations in glycosylation correlate with disease activity and clinical manifestations, and thus have potential use as biomarkers. In this review, we summarize findings on glycosylation alterations in SLE and how they relate to immune system defects and their clinical manifestations.

The purpose of this study was to evaluate the effect of the consumption of seed oils from Vitis vinifera and Arachis hypogaea in platelet aggregation. The initial hypothesis suggested that subjects who have consumed these seed oils undergo modified platelet aggregation. This study was performed using a pre–post test design, with a control group, and double blind. The effects of the consumption of grape seed and peanut oils were measured for platelet aggregation in clinical and laboratory tests in 30 healthy subjects. In addition to this group, a control group of 4 health subjects received no treatment with oils, just 500 mg oral administration acetylsalicylic acid for 7 days. Platelet aggregation was assessed by the Born turbidimetric method, using 3 different concentrations of adenosine diphosphate as agonists (2, 54; 1, 17; and 0, 58 μM). The study subjects had very similar results; both oils were shown to have a significant reduction in platelet aggregation. Grape seed oil showed a decrease of 8.4 ± 1% in aggregation, compared with peanut oil, which decreased aggregation by 10.4 ± 1%. The control group, taking 500 mg OD aspirin for 7 days, showed a significant decrease in platelet aggregation, similar to that of oil ingestion. Each of the oils was analyzed for fatty acids, to determine which particular acids were presents in greater levels, which could explain the reduction in platelet aggregation. The oil found to be most abundant in grape seeds was linoleic acid (omega-6), and in peanuts, it was oleic acid (omega-9). However, in fact, both acids reduced platelet aggregation. Consumption of plant oils from grape seeds and peanuts had a lowering effect on platelet aggregation, in addition to containing a high content of unsaturated fatty acids. However, omega-3, omega-6, and omega-9 fatty acids were not specifically responsible for the reductions mentioned above.

Vertebrate eye development is a highly organized process requiring the participation of a number of genes that act coordinately during embryogenesis to produce functional visual structures.1 Distur...

Opioid harm reduction and stigma: proposed methods to improve the perception of people with addiction