Objective: To systematically evaluate the scientific literature for patient‐reported outcome measures (PROMs) in static computer‐aided implant surgery ( s‐CAIS ). Methods: A PICO strategy was executed using an electronic ( MEDLINE , EMBASE , CENTRAL ), plus manual search up to 15‐06‐2017 focusing on clinical studies investigating s‐CAIS with regard to patients’ pain & discomfort, economics and/or intra‐operative complications. Search strategy was assembled from multiple conjunctions of Me SH Terms and unspecific free‐text words. Assessment of risk of bias in selected studies was made at a “trial level” applying the Cochrane Collaboration Tool and the Newcastle–Ottawa Assessment Scale, respectively. Results: The systematic search identified 112 titles. Seventy abstracts were screened, and 14 full texts were included for analysis. A total of 484 patients were treated with s‐CAIS for placement of 2,510 implants. Due to the heterogeneity of the included studies, meta‐analyses could not be performed. Conclusions: The number of identified studies investigating s‐CAIS for PROMs was low. Scientifically proven recommendations for clinical routine cannot be given at this time; however, the number of clinical complications with s‐CAIS seems to be negligible and comparable to conventional implant surgery. s‐CAIS may offer a beneficial treatment option in edentulous cases if a flapless approach is applicable. Nevertheless, the economic effects in terms of time efficiency and treatment costs are unclear. Clinical investigations with well‐designed RCT s investigating PROMs with standardized parameters are compellingly necessary for the field of s‐CAIS .