Prof. Alberto Marra
Institut des Biomolécules Max Mousseron (IBMM), Université Montpellier, CNRS, ENSCM, Montpellier, France
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Academic Career Length
34Years (1993-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications18 March 2014 in European Journal of Organic Chemistry
Journal Article
ADAlessandro Dondoni
Alessandro DondoniAlberto Marra23 April 2015 in New Journal of Chemistry
Journal Article
RZRenaud Zelli
Renaud Zelli
JLJean-François Longevial
Jean-François Longevial
PDpascal dumy
pascal dumyAlberto MarraClustering 1-deoxynojirimycin (DNJ), first isolated from white mulberry, and other iminosugars around various scaffolds gave strong glycosidase inhibitors.
21 April 2021 in Organic & Biomolecular Chemistry
Journal Article
ICIrene Conforti
Irene ConfortiAlberto MarraThe review describes the syntheses and inhibition properties of pyrrolidine, piperidine, azepane, pyrrolizidine and indolizidine iminosugars, as well as iminosugar nucleotides and iminodi- and -oligosaccharides.
24 January 2017 in Organic & Biomolecular Chemistry
Journal Article
ADAlessandro Dondoni
Alessandro DondoniAlberto MarraThe Sulfur(VI) Fluoride Exchange (SuFEx), revived by Sharpless and co-workers from an unrecognized state, is an emerging new click reaction that is based on the high reactivity of sulfonyl fluorides and fluorosulfates with suitable nucleophiles such as silyl ethers and amines. Hence, we comment in this Perspective on the use of SuFEx for the synthesis of a new family of sugar containing sulfonamides from the reaction of a glycosylsulfonyl fluoride with aliphatic amines. We also highlight the applications of SuFEx to multivalent scaffolds such as tetraamino- and tetrafluorosulfonyl-calixarene leading to sulfonamide-linked sugar and iminosugar clusters. Finally, we report on the chemoselective functionalization of bovine serum albumin (BSA) which, owing to the amino group of lysine moieties, reacted with SO2F2 to give a multivalent BSA–SO2F system. The PEGylation of the same protein by coupling with a PEG-fluorosulfate is described as well.
15 August 2016 in European Journal of Organic Chemistry
Journal Article
RZRenaud Zelli
Renaud Zelli
STStefano Tommasone
Stefano TommasonePDpascal dumy
pascal dumyAlberto MarraADAlessandro Dondoni
Alessandro DondoniJournal Article
EWElżbieta Wojaczyńska
Elżbieta WojaczyńskaFSFranz Steppeler
Franz SteppelerDIDominika Iwan
Dominika IwanMSMarie-Christine Scherrmann
Marie-Christine ScherrmannAlberto MarraOrganocatalysis is a very useful tool for the asymmetric synthesis of biologically or pharmacologically active compounds because it avoids the use of noxious metals, which are difficult to eliminate from the target products. Moreover, in many cases, the organocatalysed reactions can be performed in benign solvents and do not require anhydrous conditions. It is well-known that most of the above-mentioned reactions are promoted by a simple aminoacid, l-proline, or, to a lesser extent, by the more complex cinchona alkaloids. However, during the past three decades, other enantiopure natural compounds, the carbohydrates, have been employed as organocatalysts. In the present exhaustive review, the detailed preparation of all the sugar-based organocatalysts as well as their catalytic properties are described.
About Me
Alberto Marra graduated in Pharmaceutical Sciences from the University of Pisa (Italy) and obtained his PhD degree from the University of Paris VI (France) under the supervision of Prof. P. Sinaÿ (Ecole Normale Supérieure). After a post-doctoral fellowship at the University of Zurich (Switzerland) with Prof. A. Vasella, he joined the group of Prof. A. Dondoni at the University of Ferrara (Italy). In 1998 he became Professor in Organic Chemistry, and in 2012 he moved to the University of Montpellier (France) where he joined the Institute of Biomolecules Max Mousseron (IBMM). Since 2015 he has been leading the Glycochemistry and Molecular Recognition team at IBMM. Since 2018 he has been the Editor-in-Chief of Letters in Organic Chemistry (Bentham Science). His recent work deals with the synthesis of multivalent sugars and iminosugars through metal-free ligations such as the thiol-ene coupling (TEC), thiol-yne coupling (TYC) and sulfur(VI) fluoride exchange (SuFEx).