Cristian Nicolae Bulescu

Mr. Cristian Nicolae Bulescu

Congenital Cardiac Surgery, Hôpital Louis Pradel, Lyon, Auvergne-Rhône-Alpes, France
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Research Focus & Metrics

Academic Career Length

11Years (2016-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 November 2023 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
Corina Maria VasileCorina Maria Vasile
Corina Maria Vasile
GLGerald Laforest
Gerald Laforest
CBCristian Nicolae Bulescu
Cristian Nicolae Bulescu
ZJZakaria Jalal
Zakaria Jalal
JTJean-Benoit Thambo
Jean-Benoit Thambo
Xavier IriartXavier Iriart
Xavier Iriart
First described in 1760 by the anatomist Morgagni, coarctation of the aorta (CoA) is a congenital heart defect characterized by narrowing the aorta, typically distal to the left subclavian artery. It accounts for approximately 5–8% of all congenital heart diseases, with an incidence estimated at 4 per 10,000 live births. In 1944, the Swedish surgeon Clarence Crafoord achieved the first successful surgical CoA repair by performing an aortic end-to-end anastomosis on two patients aged 12 and 27 years old. Presently, the most prevalent techniques for surgical repair, particularly in infants and neonates with isolated coarctation, involve resection with end-to-end anastomosis (EEA) and the modified Crafoord technique (extended resection with end-to-end anastomosis (EEEA)). Subclavian flap aortoplasty (SCAP) is an alternative surgical option for CoA repair in patients under two years of age. In cases where the stenosis extends beyond resection and end-to-end anastomosis feasibility, patch aortoplasty (PP) employing a prosthetic patch can augment the stenotic region, especially for older patients. Despite advances in pediatric cardiology and cardiac surgery, recoarctation remains a significant concern after surgical or interventional repair. This comprehensive review aims to provide a thorough analysis of coarctation management, covering the pioneering techniques introduced by Crafoord using end-to-end anastomosis and now extending to the contemporary era marked by percutaneous interventions as well as the recoarctation rate associated with each type.

Verified
Journal Article
Open access
PDF file
Catalin Gabriel HerghelegiuCatalin Gabriel Herghelegiu
Catalin Gabriel Herghelegiu
Ana-Maria ZagreanAna-Maria Zagrean
Ana-Maria Zagrean
SDSimona Duta
Simona Duta
AVAna Maria Vayna
Ana Maria Vayna
Anca Marina CiobanuAnca Marina Ciobanu
Anca Marina Ciobanu
AVAlina Veduta
Alina Veduta
Congenital heart disease (CHD) is the most common birth defect, with a reported prevalence of 5–12 per 1000 live births. Very recently, the American Institute of Ultrasound in Medicine published a guideline recommending the use of the four-chamber and the three-vessel and trachea views to screen for CHD in the first trimester of pregnancy. Our aim is to present abnormal image patterns that are seen in the four-chamber, three-vessel, and trachea views of the fetal heart in the first trimester and to describe their association with specific CHD types. We used a total of 29 cases of CHD from the archives of Filantropia Hospital and the Maternal and Child Health Institute (INSMC) fetal medicine units. We selected cases with a clear and well-documented diagnosis of the CHD type. We identified a series of repeating color doppler flow patterns seen in the four-chamber, three-vessel, and trachea views of the studied cases. Our observations could be developed into a diagnosis algorithm to orientate the examiner to the most likely type of CHD in individual cases.

28 October 2021 in Medicina
Verified
Journal Article
Open access
PDF file
Horațiu MoldovanHorațiu Moldovan
Horațiu Moldovan
CBCristian Nicolae Bulescu
Cristian Nicolae Bulescu
ASAndra Sibisan
Andra Sibisan
RTRobert Tiganasu
Robert Tiganasu
MCMihai Cacoveanu
Mihai Cacoveanu
ASAlexandru Scafa-Udriste
Alexandru Scafa-Udriste
We present the case of a 50-year-old male, with no cardiovascular risk factors other than smoking, that presented with acute chest pain, revealed to be an acute myocardial infarction with a large thrombus located in the ascending aorta. Such findings are rare in a patient with no other afflictions, such as atherosclerosis, aortic aneurysm, or aortic wall injury (surgical or traumatic). There is no specific pathway regarding the management of ascending aorta thrombus in such a patient; therapeutic options include surgical, interventional, or medical methods. Surgical thrombectomy was performed in this case, considering the high risk of systemic embolism and stroke and the hemodynamic stability of the patient.

22 November 2024 in Transplantation Reviews
Verified
Journal Article
Open access
ABAbdulaziz Abdulelah Banaja
Abdulaziz Abdulelah Banaja
CBCristian Nicolae Bulescu
Cristian Nicolae Bulescu
CMCaroline Martin-Bonnet
Caroline Martin-Bonnet
MLMarc Lilot
Marc Lilot
RHRoland Henaine
Roland Henaine
The rising prevalence of congenital heart disease (CHD) among adults has led to increased heart transplantation (HT) procedures in this population. However, CHD patients face significant challenges including longer waiting times, higher early mortality rates, and increased risks of complications such as renal dysfunction. This systematic review and meta-analysis examined 50 studies to assess waiting times, postoperative outcomes, and survival rates in CHD patients undergoing HT compared to non-CHD patients. Results revealed that CHD patients experience longer HT waiting times (mean difference [MD]: 53.86 days, 95 % CI: [22.00, 85.72], P = 0.0009) and increased ischemic times (MD: 20.01 min, 95 % CI: [10.51, 29.51], P < 0.0001), which may increase waitlist and early postoperative mortality. Regarding complications, renal dysfunction is more prevalent in CHD patients than in non-CHD patients (RR: 2.05, 95 % CI: [1.61, 2.61], P < 0.00001). Despite these challenges, long-term survival rates for CHD patients are comparable to those of non-CHD recipients, with significant improvements noted in recent allocation systems. Our findings emphasize the need for ongoing refinements in HT allocation systems to improve outcomes for CHD patients, particularly in reducing waiting times and managing post-transplant complications.

19 October 2023 in Preprints.org
Verified
Preprint
Open access
PDF file
Corina Maria VasileCorina Maria Vasile
Corina Maria Vasile
GLGerald Laforest
Gerald Laforest
CBCristian Nicolae Bulescu
Cristian Nicolae Bulescu
ZJZakaria Jalal
Zakaria Jalal
JTJean-Benoit Thambo
Jean-Benoit Thambo
Xavier IriartXavier Iriart
Xavier Iriart
First described in 1760 by the anatomist Morgagni, CoA is a congenital heart defect characterized by narrowing the aorta, typically distal to the left subclavian artery. It accounts for approximately 5-8% of all congenital heart diseases, with an incidence estimated at 4 per 10,000 live births. In 1944, the Swedish surgeon Clarence Crafoord achieved the first successful surgical CoA repair by performing an aortic end-to-end anastomosis on two patients aged 12 and 27 years old. Presently, the most prevalent techniques for surgical repair, particularly in infants and neonates with isolated coarctation, involve resection with end-to-end anastomosis (EEA) and the modified Crafoord technique (extended resection with end-to-end anastomosis (EEEA)). Subclavian flap aortoplasty (SCAP) is an alternative surgical option for CoA repair in patients under two years of age. In cases where the stenosis extends beyond resection and end-to-end anastomosis feasibility, patch aortoplasty (PP) employing a prosthetic patch can augment the stenotic region, especially for older patients. Despite advances in pediatric cardiology and cardiac surgery, recoarctation remains a significant concern after surgical or interventional repair. This comprehensive review aims to provide a thorough analysis of coarctation management, covering the pioneering techniques introduced by Crafoord using head-to-tail anastomosis and now extending to the contemporary era marked by percutaneous interventions as well as the recoarctation rate associated with each type.

30 November 2021 in World Journal for Pediatric and Congenital Heart Surgery
Verified
Journal Article
Closed access
PDF file
DADaouda Amadou
Daouda Amadou
JMJulia Mitchell
Julia Mitchell
CBCristian Nicolae Bulescu
Cristian Nicolae Bulescu
OMOlivier Metton
Olivier Metton
RHRoland Henaine
Roland Henaine
JNJean Ninet
Jean Ninet
Background: Anomalous aortic origin of the right coronary artery is known to be a cause of sudden cardiac death in athletes. There are no specific guidelines concerning treatment strategy in the literature. The aim of this study is to describe and report our experience of direct reimplantation technique in the treatment of this anomaly. Methods: This was a retrospective single center study of 30 patients who underwent surgery in the congenital heart disease unit of Louis Pradel Heart and Lung Hospital between January 2003 and December 2016. The mean follow-up was seven years (3 months-17 years). Results: Thirty patients underwent surgery. The median age was 17 years (0.2-52 years). There were 24 males. The median weight was 58 kg (3.6-118 kg). Fourteen patients were actively engaged in sports. Twenty-six patients had exertional chest pain or syncope. The median time lapse between diagnosis and intervention was 4.5 months (0.5-179 months). Twenty-seven (90%) patients underwent reimplantation of the anomalous coronary artery without transverse aortotomy, while in 3 (10%) patients transverse aortotomy was used to facilitate reimplantation to avoid tension at the anastomosis. There was no early death; one late death occurred in the third postoperative month. At the last follow-up, all patients had returned to normal physical activity without evidence of ischemia. Conclusions: Direct reimplantation allows for a complete restoration of the coronary anatomy and enables patients to return to normal physical activity. Our study shows encouraging results using a direct reimplantation technique without aortotomy.