Ratnakar Tripathi

Dr. Ratnakar Tripathi

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Biography

I am an ocular researcher with a background in human genetics, cellular and molecular biology in vision science. My research interests are ocular diseases and their molecular basis of disease pathogenesis, and the development of therapeutic approaches to prevent blindness. During my Ph.D., I have studied and reported putative interactors of Pax6 (a master regulator gene of the brain and eye development). The Pax6 interactors are critical in regulating neuronal plasticity, migration, and modulating memory formation, and play an important role in brain aging. In 10 years of my research career, I have worked on human genetics, neuroscience of brain aging, memory formation, and ocular research, published several research articles in National and International peer-reviewed and indexed journals, co-authored a book chapter, and received multiple awards from National and International organizations. Currently, I am working on corneal wound healing biology, gene therapy, epigenetic, and nanomedicine approaches to treat corneal fibrosis. My current research is focused on studying corneal fibrosis and the toxicity of threat chemicals to the eye. I have contributed, to defining tissue-targeted gene therapy approaches for the cornea, and successfully demonstrated their bench-to-bedside translational potential by employing various genes (decorin, BMP7, soluble-TGFβRII, Smad7) for corneal fibrosis and neovascularization treatment in-vivo using rabbit models. Recently I have reported CRISPR

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