Through a systematic literature review, this article aims to evaluate the impacts of various concepts of pro-poor innovations (PPI) on the five instrumental freedoms in Amartya Sen’s Capability Approach. For this, 165 articles were analysed to summarize the main influences of the pro-poor innovation on each type of instrumental freedom: political freedoms, economic facilities, transparency guarantees, social opportunities, and protective security. In general, the results indicate a positive influence of the innovation concepts for distinct types of freedom, with emphasis on the expansion of social opportunities and economic facilities.