Although proliferation of keratinocytes, a major type of skin cells, is a key factor in maintaining the function of skin, their ability to proliferate tends to diminish with age. To solve such a problem, researchers in medical and skin cosmetic fields have tried to utilize epidermal growth factor (EGF), but achieved limited success. Therefore, a small natural compound that can mimic the activity of EGF is highly desired in both medical and cosmetic fields. Here, using the modified biosensor system, we observed that natural small-compound isoprocurcumenol, which is a terpenoid molecule derived from turmeric, can activate EGFR signaling. It increased the phosphorylation of ERK and AKT, and upregulated the expression of genes related to cell growth and proliferation, such as c-myc, c-jun, c-fos, and egr-1. In addition, isoprocurcumenol induced the proliferation of keratinocytes in both physical and UVB-induced cellular damage, indicative of its function in skin regeneration. These findings reveal that EGF-like isoprocurcumenol promotes the proliferation of keratinocytes and further suggest its potential as an ingredient for medical and cosmetics use.

Blue carbon ecosystems are crucial for carbon sequestration on a global scale. However, it is unclear how we could promote and maximize carbon sequestration. Here, we demonstrate that providing an iron source to seaweed fostered its growth through increased photosynthetic efficiency and transformed the carbon into a biomass. Firstly, we revealed that the mixture of the steel slag and DTPA eluted iron dramatically in seawater. Next, we applied the eluate of the slag-DTPA pellet to the seaweed. The results for the eluate treatment showed a 25.8% increase in the photosynthetic pigment level and a 44.9% increase in the seaweed weight. Furthermore, we confirmed no elution of potential toxic substances from the steel slag and DTPA pellet. Finally, we applied the pellet at a depth of 15 m near seaweeds and observed a 52.0% increase of carbon weight in the pellet treated group, while the non-treated group showed only a 10.3% increase for five months. This study indicated that steel slag-DTPA pellet treatment induced seaweed growth and efficiently transformed its carbon into a seaweed biomass. Thus, steel slag and its chelating agent may contribute to the promotion of sea forestation and a subsequent increase in carbon sequestration known as blue carbon.