The study aimed to assess the human health risk of PM_2.5-bound heavy metals from anthropogenic sources in Khon Kaen Province, Thailand between December 2020 and February 2021. According to the findings, the geometric mean concentration of PM_2.5 in the university area, residential area, industrial zone, and the agricultural zone was 32.78 μg/m³, 50.25 μg/m³, 44.48 μg/m³, and 29.53 μg/m³, respectively. The results showed that the estimated human health risk assessment, in terms of non-carcinogenic risks among children and adults in an urban area (residential and university), industrial zone, and the agricultural area, was of hazard index (HI) value of >1.0 indicating a greater chance of chronic effects occurring. This study showed that exposure to PM_2.5-bound heavy metal may increase the likelihood that lasting effects will result in a very high carcinogenic risk (CR) in children in residential areas, and an industrial zone with total carcinogenic risk (TCR) values of $0.23\times {10}^1$, and $0.12\times {10}^1$, respectively while resulting in a high TCR of $3.34\times {10}^{-2}$ and $4.11\times {10}^{-2}$ within the university areas and agricultural zone, respectively. In addition, health risk assessments among adults demonstrate high TCR values of $4.40\times {10}^{-1}$ (residential area), $2.28\times {10}^{-1}$ (industrial zone), and $7.70\times {10}^{-3}$ (agricultural zone), thus indicating a potential health risk to adults living in these areas while the university area was very low effects on carcinogenic risk ($\mathrm{CR}\le {10}^{-8}$) for adults. Therefore, lowering the risk of exposure to PM_2.5 via the respiratory tract, for example, wearing a mask outside is a very effective self-defense strategy for people within and around the study site. This data study strongly supports the implementation of the air pollutant emission source reduction measures control and health surveillance.

Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Cancer Risk in a Nested Case-Control Study in North-East Thailand Cervical cancer;nested case-control study;Chlamydia infection;Northeast Thailand; Cervical cancer continues to be an important public health problem in Thailand. While the high risk human papillomavirus (HPV) types have been established as the principle causative agent of both malignancies and the precursor lesions, cervical intraepithelial neoplasia (CIN), other factors may also be involved like other sexually transmitted diseases, as well as smoking. Chlamydia trachomatis is an obligate intracellular Gramnegative bacterium which has a tendency to cause chronic infection featuring inflammation and therefore might be expected to increase the risk of cervical cancer. In the present nested case-control study, 61 cases of cervical cancer and 288 matched controls with original serum samples were identified from the Khon Kaen Cohort, established in the North-East of Thailand, by linkage to the Khon Kaen population based cancer registry. C. trachomatis specific IgG antibodies at recruitment were measured by microimmunofluorescence and assessed for association with cervical cancer using STATA release10. No significant link was noted either with all cancers or after removal of adenocarcinomas. The results suggest no association between Chlamydia infection and cervical cancer development in North-East Thailand, but possible influencing factors must be considered in any future research on this topic.

Volatile organic compounds (VOCs) are a complex group of chemicals that pose a direct risk to human health. They also lead to the formation of other air pollution constituents, including fine particulate matter (PM_2.5) and ground level ozone (O₃). The ambient air concentrations of 19 VOCs were measured using multi-day 24 h sampling at two urban sites and two rural sites in the area of Khon Kaen, Thailand. Results showed that most VOCs were at concentrations considered acceptable according to the 24 h average standards established by the Thai Pollution Control Department. The VOC acrolein, however, was detected at concentrations (0.69–1.15 μg/m³) in excess of the 24 h average standard (0.55 μg/m³). Two other VOCs, benzene and 1,3-butadiene, were also detected at elevated levels (1.73–2.75 and 0.18–0.40 μg/m³, respectively) that indicated the potential to exceed the 1-year average standard. VOC concentrations were highest in the urban market monitoring site, suggesting that vehicle exhaust and food preparation using cooking oil at high temperatures may have been potential sources of the elevated VOCs.

The impact of air pollution is a major public health concern. However, there are few studies on the correlation between PM_2.5 and respiratory infections. This study aimed to determine a link between PM_2.5 and respiratory diseases among the elderly in Thailand. The data source for this study consisted of 43 electronic files from the Khon Kaen Provincial Health Office covering years 2020 and 2021 and surveyed a total of 43,534 people. The generalized linear mixed model (GLMM) was used to determine the adjusted odds ratio (AOR), and 95 % CI. We found that exposure to PM_2.5 concentrations (in 10 μg m⁻³ increments) was associated with respiratory diseases (AOR: 3.98; 95 % CI [1.53–10.31]). Respondents who are male, aged less than 80 years, single, self-employed, or working as contractors, have a body mass index (BMI) not equal to the standard, have NCDs (hypertension, diabetes mellitus, and cardiovascular disease), are smokers, live in sub-districts where more than 5 % of the land is planted to sugarcane, or live in close proximity to a biomass power plant were at significantly higher risk of developing respiratory diseases (p<0.05). Therefore, environmental factors including ambient PM_2.5 concentrations, the proportion of sugarcane plantation areas, and biomass power plants impact the occurrence of respiratory diseases among the elderly. Also, demographic factors and NCDs are serious issues. Systematic approaches to reducing PM_2.5 levels in industrial and agricultural sectors are necessary for both the general population and vulnerable groups, including the elderly and NCD patients.