The effect of Stefan blowing on the Cattaneo–Christov characteristics of the Blasius–Rayleigh–Stokes flow of self-motive Ag-MgO/water hybrid nanofluids, with convective boundary conditions and a microorganism density, are examined in this study. Further, the impact of the transitive magnetic field, ablation/accretion, melting heat, and viscous dissipation effects are also discussed. By performing appropriate transformations, the mathematical models are turned into a couple of self-similarity equations. The bvp4c approach is used to solve the modified similarity equations numerically. The fluid flow, microorganism density, energy, and mass transfer features are investigated for dissimilar values of different variables including magnetic parameter, volume fraction parameter, Stefan blowing parameter, thermal and concentration Biot number, Eckert number, thermal and concentration relaxation parameter, bio-convection Lewis parameter, and Peclet number, to obtain a better understanding of the problem. The liquid velocity is improved for higher values of the volume fraction parameter and magnetic characteristic, due to the retardation effect. Further, a higher value of the Stefan blowing parameter improves the liquid momentum and velocity boundary layer thickness.