Alae El Haitami

Dr. Alae El Haitami

orcid

Research Focus & Metrics

Academic Career Length

8Years (2019-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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18 December 2019 in Science Robotics
Verified
Journal Article
Open access
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XJXiaobin Ji
Xiaobin Ji
XLXinchang Liu
Xinchang Liu
VCVito Cacucciolo
Vito Cacucciolo
MIMatthias Imboden
Matthias Imboden
YCYoan Civet
Yoan Civet
HSHerbert Shea
Herbert Shea
Low-voltage dielectric elastomer actuators propel an autonomous untethered subgram robust soft legged robot along complex paths.

7 October 2020 in Advanced Functional Materials
Verified
Journal Article
Closed access
PDF file
XJXiaobin Ji
Xiaobin Ji
XLXinchang Liu
Xinchang Liu
VCVito Cacucciolo
Vito Cacucciolo
YCYoan Civet
Yoan Civet
AHAlae El Haitami
Alae El Haitami
HSHerbert Shea
Herbert Shea

31 October 2024 in Angewandte Chemie International Edition
Verified
Journal Article
Open access
ABAndrea Barba‐Bon
Andrea Barba‐Bon
AHAlae El Haitami
Alae El Haitami
CPCoralie Pasquier
Coralie Pasquier
INIvana Nikšić-Franjić
Ivana Nikšić-Franjić
ODOlivier Diat
Olivier Diat
WNWerner M. Nau
Werner M. Nau
Boron clusters are applied in medicinal chemistry because of their high stability in biological environments and intrinsic ability to capture neutrons. However, their intermolecular interactions with lipid membranes, which are critical for their cellular delivery and biocompatibility, have not been comprehensively investigated. In this study, we combine different experimental methods – Langmuir monolayer isotherms at the air–water interface, calorimetry (DSC, ITC), and scattering techniques (DLS, SAXS) – with MD simulations to evaluate the impact of closo‐dodecaborate clusters on model membranes of different lipid composition. The cluster anions interact strongly with zwitterionic membranes (POPC and DPPC) via the chaotropic effect and cause pronounced expansions of lipid monolayers. The resulting lipid membranes contain up to 33 mol % and up to 52 weight % of boron cluster anions even at low aqueous cluster concentrations (1 mM). They show high (μM) affinity to the hydrophilic‐hydrophobic interface, affecting the structuring of the lipid chains, and therefore triggering a sequence of characteristic effects: (i) an expansion of the surface area per lipid, (ii) an increase in membrane fluidity, and (iii) a reduction of bilayer thickness. These results aid the design of boron cluster derivatives as auxiliaries in drug design as well as transmembrane carriers and help rationalize potential toxicity effects.

9 December 2019 in SN Applied Sciences
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Journal Article
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ARAdeline Royaux
Adeline Royaux
AHAlae El Haitami
Alae El Haitami
OFOdile Fichet
Odile Fichet
SCSophie Cantin
Sophie Cantin

2 December 2021 in Applied Sciences
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DGDavide Geremia
Davide Geremia
CDChristian DAVID
Christian DAVID
RIRachid Ismail
Rachid Ismail
AHAlae El Haitami
Alae El Haitami
We investigated the impact of water weakening on the mechanical behavior of Obourg Chalk and Ciply Chalk (Mons Basin, Belgium). Different mechanical tests were conducted to estimate the unconfined compressive strength (UCS), tensile strength, Young’s modulus, mechanical strength under triaxial loading, critical pressure, fracture toughness, cohesion, and internal friction coefficient on samples either dry or saturated with water or brine. This extensive dataset allowed us to calculate wet-to-dry ratios (WDR), i.e., the ratio between any property for a dry sample to that for the water-saturated sample. For both chalks, we found that water has a strong weakening effect with WDR ranging from 0.4 to 0.75. Ciply Chalk exhibits more water weakening than Obourg Chalk. The highest water weakening effect was obtained for UCS, critical pressure, and Young’s modulus. Weakening effects are still present in brine-saturated samples but their magnitude depends on the fluid composition. The mechanical data were correlated to variations in surface energy derived from three different methods: fracture mechanics, contact angle goniometry, and atomic force microscopy. Water weakening in the tested chalks can be explained by a clear reduction in surface energy and by the existence of repulsive forces which lower the cohesion.

15 July 2024 in Macromolecules
Verified
Journal Article
Closed access
HFHugo Fernandez
Hugo Fernandez
AHAlae El Haitami
Alae El Haitami
SSSylvie Spagnoli
Sylvie Spagnoli
PFPhilippe FONTAINE
Philippe FONTAINE
SCSophie Cantin
Sophie Cantin