Prof. Dr. Jose V. Castell is an Emeritus Professor of Biochemistry and Molecular Biology at the University of Valencia. He holds a PhD in Science, a PhD in Medicine and a degree in Pharmacy from the University of Valencia. He earns his Postdoctoral degree from the ETH-Zürich and Max-Planck Institut, Göttingen. He worked as an Invited professor at the Biochemisches Institut de Univesität Freiburg. In 1990, he was given the International Award of the European Federation of Pharmaceutical Industries (Heidelberg 1990) for the development of cultured human hepatocytes to investigate the hepatotoxic risk of new drugs to man. He is a former member of the Scientific Advisory Committee of the European Center for Validation of Alternative Methods (ECVAM), the Scientific Committee of INVITOX, and the Scientific Committee ILSI. He has been actively involved in over 25 EU research projects; and has served as coordinator in 3 of them. He has authored 410 papers, including scientific articles published in relevant international journals, book chapters, and several reviews. His major research interests include: in vitro drug metabolism and hepatotoxicity, drug-induced liver injury in clinics, cell reprogramming to hepatocytes, cell therapy with human hepatocytes and PSC-derived hepatocytes.