Objective: Due to ongoing technical progress, the ultrasonic measurement of blood pressure (BP) as an alternative to oscillometric measurement (NIBP) or the continuous non-invasive arterial pressure method (CNAP) moves further into focus. The US method offers several advantages over NIBP and CNAP, such as deep tissue penetration and the utilization of different arterial locations. Approach: Ten healthy subjects (six female, aged 30.9 ± 4.6 years) volunteered in our investigation. In the ultrasonic BP measurement, we differentiated between the directly measured (pulsatile diastolic and systolic vessel diameter) and indirectly calculated variables at three different artery locations on both arms, with two different ultrasound devices in the transversal and longitudinal directions of the transducer. Simultaneously, NIBP monitoring served as reference BP, while CNAP monitored the steady state condition of the arm under investigation. The Moens–Korteweg algorithm (MKE) and the algorithm of the working group of San Diego (SanD) were selected for the indirectly calculated ultrasonic BP data. Main results: With US, we were able to measure the BP at each selected arterial position. Due to the investigation setup, we found small but significant interactions of the main effects. Bland and Altman analysis revealed that US-BP measurement was similar to NIBP, with superior accuracy when compared to the established CNAP method. In addition, US-BP measurement showed that the measurement accuracy of both arms can be regarded as identical. In a detailed comparison of the selected arterial vascular sections, systematic discrepancies between the right and left arm could be observed. Conclusion: In our pilot study, we measured BP effectively and accurately by US using two different devices. Our findings suggest that ultrasonic BP measurement is an adequate alternative for live and continuous hemodynamic monitoring.

Objective: The main objective of this investigation is to provide data about the accuracy of total hemoglobin concentration measurements with respect to clinical settings, and to devices within the categories of point-of-care and reference systems. In particular, tolerance of hemoglobin concentrations below 9 g/dL that have become common in clinical practice today determines the need to demonstrate the limits of measurement accuracy in patient care. Methods: Samples extracted from six units of heparinized human blood with total hemoglobin concentrations ranging from 3 to 18 g/dL were assigned to the test devices in a random order. The pool of test devices comprised blood gas analyzers, an automatic hematology analyzer, a laboratory reference method, and the point-of-care system HemoCue. To reduce the pre-analytic error, each sample was measured three times. Due to the characteristics of the tested devices and methods, we selected the mean values of the data from all these devices, measured at the corresponding total hemoglobin concentrations, as the reference. Main results: The measurement results of the test devices overlap within strict limits (R² = 0.999). Only the detailed analysis provides information about minor but systematic deviations. In the group of clinically relevant devices, which are involved in patient blood management decisions, the relative differences were within the limit of +/− 5 % for values down to 3 g/dL. Conclusions: A clinically relevant change of +/− 0.5 g/dL of total hemoglobin concentration can be detected with all selected devices and methods. Compliance with more stringent definitions—these are the relative differences of 5 % in relation to the corresponding reference values and the clinically adapted thresholds in the format of a tolerance level analysis—was achieved by the clinical devices assessed here.

Die offene Sauerstoffgabe bei Patienten unter Sedierung und die Anwendung von Elektrokoagulation führen die Hitliste im Risikoprofil von Feuer, Brand, oder gar einer Explosion (FBE) in der Nähe von Menschen im OP. Das wesentliche Risiko ist das Dreieck „Oxidation – Zündenergie – entzündbares Material“ (OZE). Ein hohes Risiko haben Eingriffe innerhalb oder in der Nähe des Luftwegs bei Anwendung von Laserenergie. Insgesamt treffen diese Ereignisse selten, aber mit steigender Tendenz und meist vollkommen unerwartet ein. Die verheerenden Konsequenzen sowie – bei sachgerechter Durchführung – die mögliche Vermeidung unterstreichen die Frage, mit welchen Maßnahmen das Risiko reduziert oder das Ereignis gar verhindert werden kann. Feuer, Brand und Explosion (FBE) im Operationssaal sind seltene, aber mit schweren personellen und materiellen Schäden einhergehende Ereignisse. Mit dem notwendigen Hintergrundwissen und einer Präventionsstrategie sind diese Ereignisse trotz zunehmendem Einsatz der Laser- und Diathermietechnik grundsätzlich vermeidbar. Die Autoren zeigen die besondere Rolle der Anästhesie und die Notwendigkeit der Absprachen innerhalb des gesamten Operationsteams auf. The combination of an oxidant source, ignition energy and flammable material is the reason for fire, burning and explosion (FBE) in the OR. Attending anaesthesiologists face these risks in their daily routine. Mostly, a situation with FBE arises in an unexpected situation. It is essential to have at hand a catalogue of measures to prevent severe injuries to patients and avoid material damages. There is a systematic way to decrease the risk: awareness and definition of high-risk situations; team work; building up a strategy to avoid the occurrence of fire, burning and explosion in high-risk situations. The risk profile should be part of security checklists. If there is physical injury caused by fire in the OR, the extent of trauma must be assessed and documented. Finally, an interdisciplinary review may be indicated. Institutional standards regarding risk- and quality management, e. g. working place orders and measures of fire prevention, increase patient security. Systematic implementation of measures and annual training sessions are indispensable.

Objective: Accurate total hemoglobin concentration (ctHb) measurement is critical for clinical decision-making, particularly in acute care, where immediate therapeutic decisions are required. This study evaluated previously established laboratory-based accuracy criteria for ctHb measurements in routine clinical practice at an interdisciplinary operative intensive care unit (IO-ICU), and with particular attention to significantly reduced hemoglobin concentrations. Method: Remaining blood from blood gas analysis (BGA) cuvettes was collected directly at the ICU bedside. From these initial samples, three clinically relevant measurement scenarios were established: direct bedside measurement (Group 01), elevated ctHb levels (Group 02), and lowered ctHb concentrations below 9 g/dl (Group 03). The samples were analyzed using the GEM 4000, GEM 5000 (Werfen GmbH, Muenchen, Germany), ABL90 Flex plus (Radiometer GmbH, Krefeld, Germany), HemoCue Hb 201+, and XN 9000/9100 (Sysmex Deutschland GmbH, Norderstedt, Germany) automatic hematology analyzers. Since each measurement device inherently possesses systematic deviations, no single analyzer was defined as an absolute reference. Instead, the mean value across all tested measurement systems was utilized as a best-fit reference (REF) value. Results: A total of 120 data pairs from 40 ICU patients were analyzed using regression analyses, Bland and Altman (B&A) methods, and tolerance level analysis (TLA). The results demonstrated strong concordance among the evaluated measurement devices across the examined ctHb spectrum (~1–18 g/dL). Moderate systematic deviations identified by B&A analysis were most pronounced at critically low ctHb levels (<6 g/dL). A key outcome was the determination of 95% prediction intervals (PIs), representing a quantifiable range of uncertainties for future bedside measurements. The PIs for Group 03 “low” were in the range of ±7% (relative difference) or ±0.38 g/dL (absolute difference). Conclusion: This study effectively translates previous laboratory findings into clinical practice, highlighting the practical utility of PIs to guide the accurate interpretation of bedside ctHb measurements under acute care conditions.