Tramadol represents a synthetic opioid analgesic especially for mild to severe pain. Its dose must be commonly monitored according to pain status and to alleviate the appearance of any adverse effects such as renal cellular damage during its excretion. Present work aimed mainly to study the effects of tramadol intake on renal tissues and 10-dehydrogingerdione (10-DHGD) potential as a protective agent. Tramadol administration induced an increase in serum levels of urea, creatinine, uric acid, the renal immune expression of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and caspase-3 which turned out to be decreased by 10-DHGD intake. Our results also recorded a significant increase in renal malondialdehyde (MDA), toll-like receptor 4 (TLR4), and extracellular signal-regulated protein kinase-1 (ERK1) along with glutathione (GSH), superoxide dismutase (SOD), and heme oxygenase-1 (HO-1) decrease due to tramadol intake, which were counteracted by 10-DHGD administration as illustrated and supported by the histopathological findings. Our conclusion refers to renoprotective potential of 10-DHGD against tramadol adverse effects.

Veitchia arecina Becc. (Arecaceae family), a palm species known for its antioxidant and anti-inflammatory properties, attributed to bioactive constituents that may facilitate wound healing and enhance dermatological health. However, the wound-healing efficacy of Veitchia arecina remains uninvestigated. This study is the first to evaluate the chemical composition, antioxidant and anti-inflammatory activities, dermal safety, and wound-healing potential of Veitchia arecina leaf fractions in a rat model. The study aimed to elucidate their mechanism of action in tissue regeneration. The chemical composition of light petroleum ether and n- butanol soluble fractions of Veitchia arecina was analyzed via gas–liquid chromatography–mass spectrometry (GLC-MS) and liquid chromatography–electrospray ionization tandem mass spectrometry (LC–ESI–MS/MS), respectively. In-vitro antioxidant (DPPH), anti-inflammatory (COX-1), and MTT assays were performed utilizing a 5% gel formulation, with povidone-iodine serving as the standard. The phytochemical analysis of the tested fractions using GLC-MS and LC–ESI–MS/MS revealed the presence of sterols, terpenes, vitamin E isomers, and fatty acids in light petroleum ether soluble fraction as well as flavonoid glycosides and phenolics in n- butanol soluble fraction. Both fractions showed significant antioxidant and COX-1 inhibitory activities comparable to Trolox and ibuprofen. The topical gel formulations exhibited no dermal toxicity while improving healing by attenuating inflammation and oxidative stress, enhancing blood vessel formation, re-epithelization, formation of collagen, and restoring skin architecture. Notably, the n -butanol fraction demonstrated superior efficacy in facilitating granulation tissue maturation. This study demonstrates the dermal safety, antioxidant, anti-inflammatory, and wound-healing properties of Veitchia arecina leaf fractions, particularly flavonoid-rich variants, suggesting their potential therapeutic applications in dermatological conditions.