A widespread reliance on pesticides in agriculture has raised concerns regarding the increased risks of exposure among individuals living in agricultural communities. This article presents urinary pesticide metabolite concentrations for 665 participants in the “Study of Secondary Exposure to Pesticides among Children, Adolescents, and Adults” (ESPINA), which were collected during two follow-up assessments: July to October 2016 (Follow-up Year [FUY]-8b; n = 529) and July to September 2022 (FUY-14a; n = 505) in the agricultural community of Pedro Moncayo, Ecuador. Using first morning void urine samples, concentrations of 19 pesticides or their metabolites were measured including four organophosphates, three pyrethroids, and six neonicotinoids insecticides, two herbicides, two fungicides, and two insect repellents, for the 2016 examination (FUY-8b). In the 2022 examination (FUY-14a), fourteen biomarkers were measured, including four organophosphates, three pyrethroids, three neonicotinoids, two sulfoximines, and one butanolide insecticides, and one herbicide. We present wet weight, urinary-creatinine-adjusted concentrations (2016) and specific-gravity-adjusted concentrations (2016 and 2022).

Dietary acid load (DAL) may be associated with all-cause mortality (ACM) and breast cancer-specific mortality (BCM), and these associations may be modified by serum polychlorinated biphenyl (PCB) levels. Participants included 519 women diagnosed with first primary in situ or invasive breast cancer in 1996/1997 with available lipid-corrected PCB data. After a median of 17 years, there were 217 deaths (73 BCM). Potential renal acid load (PRAL) and net endogenous acid production (NEAP) scores calculated from a baseline food frequency questionnaire estimated DAL. Cox regression estimated covariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between PRAL and NEAP with mortality. We evaluated effect measure modification by total serum PCB levels (>median vs. ≤median). PRAL quartile 4 versus quartile 1 was associated with an ACM HR of 1.31 (95%CI = 0.90–1.92). In the upper median of PCBs, ACM HRs were 1.43 (95%CI = 0.96–2.11) and 1.40 (95%CI = 0.94–2.07) for PRAL and NEAP upper medians, respectively. In the lower median of PCBs, the upper median of NEAP was inversely associated with BCM (HR = 0.40, 95%CI = 0.19–0.85). DAL may be associated with increased risk of all-cause mortality following breast cancer among women with high total serum PCB levels, but inversely associated with breast cancer mortality among women with low PCB levels.